Photoinduced hyperthermia possesses great potential in photothermal therapy and thermal-responsive chemotherapy of tumors. However, traditional thermal-triggered drug release requires high temperature, which results in unpleasant activation of thermal-induced cellular self-protection. In this work, a Cu-complex modified and drug-loaded liposomal nanoplatform was constructed for endogenous H₂S-activated synergistic ablation of colorectal tumors. In response to H₂S, the incorporated Cu-complex contributed to the formation of semiconductor CuS on the surface of the as-designed liposomal nanoplatform, which led to local heating under near-infrared (NIR) laser irradiation to achieve simultaneous photothermal therapy and drug release. It is noteworthy that although the drug release occurred at a mild apparent temperature, it was actually triggered by the high eigen temperature on the surface of the liposomal nanoplatform. Therefore, efficient and synergistic photothermal and chemotherapy was achieved under mild apparent temperatures. This work provides insights into achieving selective and bioactivated photothermal therapy and therefore thermal-controlled drug release without using excessive hyperthermia.

中文翻译：

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内源性 H2S 激活脂质体纳米平台在温和表观温度下协同消融结直肠肿瘤

光致热疗在肿瘤的光热治疗和热响应化疗方面具有巨大的潜力。然而，传统的热触发药物释放需要高温，这导致热诱导的细胞自我保护的激活令人不快。在这项工作中，构建了一种铜络合物修饰的载药脂质体纳米平台，用于内源性 H ₂ S 激活的结直肠肿瘤协同消融。响应 H ₂S，掺入的Cu络合物有助于在所设计的脂质体纳米平台表面形成半导体CuS，这导致在近红外（NIR）激光照射下局部加热以实现同时光热治疗和药物释放。值得注意的是，虽然药物释放发生在温和的表观温度下，但实际上是由脂质体纳米平台表面的高本征温度触发的。因此，在温和的表观温度下实现了高效且协同的光热和化学疗法。这项工作为在不使用过度热疗的情况下实现选择性和生物活化光热疗法以及因此热控药物释放提供了见解。