The activation of very inert small molecules generally requires highly reactive activating species, but the high energy of these species makes their regeneration, and thus also catalytic turnover of the reaction, difficult to achieve. Here, the authors highlight the formidable challenge of overcoming the tradeoff between activating power and catalytic turnover in the context of main-group ambiphiles.

中文翻译：

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主族双亲化合物对惰性小分子的催化活化

非常惰性的小分子的活化通常需要高反应活性的活化物质，但这些物质的高能量使其难以再生，因此也难以实现反应的催化转换。在这里，作者强调了在主族双亲化合物的背景下克服活化能和催化转换之间权衡的艰巨挑战。