ABSTRACT

1. This study evaluated the pharmacokinetic profiles of florfenicol (FF) and thiamphenicol (TP), which are synthetic bacteriostatic antimicrobial drugs, in geese after a single intravenous or oral administration, as well as seven oral doses administered at 12 h intervals. For all treatments, the dose was 30 mg/kg.

2. After single IV administration, clearance and volume of distribution were low (0.23 ± 0.03 l/h/kg and 0.57 ± 0.08 l/kg for FF, and 0.23 ± 0.04 l/h/kg and 0.59 ± 0.08 l/kg for TP, respectively). The elimination half-life was similar between products and short (2.91 ± 0.41 and 2.84 ± 0.64 h for FF and TP, respectively).

3. The single oral administration resulted in efficient absorption (bioavailability of 83.15 ± 11.48 for FF and 75.21 ± 19.56% for TP) with high maximal concentrations of 30.47 ± 2.47 and 20.02 ± 3.87 μg/ml for FF and TP, respectively. The area under the curve was 108.36 ± 14.96 and 101.81 ± 26.48 mg×h/l for FF and TP, respectively.

4. For both drugs, the two latter parameters were found to be higher compared to earlier studies on terrestrial birds. This suggested that FF and TP may be efficient in treating infections in geese caused by certain bacteria sensitive to chloramphenicol.

5. Neither drug accumulated in tissues following the oral seven doses and no adverse effects were noted in any treated animals. Thus, the selected FF and TP dosage may be considered as a safe treatment for geese.

摘要

1.这项研究评估了单次静脉内或口服给药后鹅的氟苯尼考（FF）和甲砜霉素（TP）的合成代谢抑菌抗菌药物的药代动力学特征，以及每隔12小时服用7次口服剂量的鹅。对于所有治疗，剂量均为30 mg / kg。

2.单次静脉内给药后，清除率和分布体积均较低（FF为0.23±0.03 l / h / kg和0.57±0.08 l / kg，FF为0.23±0.04 l / h / kg和0.59±0.08 l / kg TP）。产品之间的消除半衰期相近，且较短（FF和TP分别为2.91±0.41和2.84±0.64 h）。

3.单次口服可有效吸收（FF的生物利用度为83.15±11.48，TP的生物利用度为75.21±19.56％），FF和TP的最大最高浓度分别为30.47±2.47和20.02±3.87μg/ ml。对于FF和TP，曲线下的面积分别为108.36±14.96和101.81±26.48mg×h / l。

4.对于这两种药物，发现后两个参数都比早期对陆生鸟类的研究要高。这表明FF和TP可能有效治疗某些对氯霉素敏感的细菌引起的鹅感染。

5.口服七剂后，两种药物均未积聚在组织中，在任何治疗的动物中均未观察到不良反应。因此，所选择的FF和TP剂量可以被认为是鹅的安全治疗方法。