Abstract

Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a pattern recognition receptor (PRR) and is expressed on cells of different origin performing different functions. RAGE ligation leads to the initiation of a cascade of signaling events and is implicated in diseases, such as inflammation, cancer, diabetes, vascular dysfunctions, retinopathy, and neurodegenerative diseases. Because of the significant involvement of RAGE in the progression of numerous diseases, RAGE signaling has been targeted through use of inhibitors and anti-RAGE antibodies as a treatment strategy and therapy. Here in this review, we have summarized the physical and physiological aspects of RAGE biology in mammalian system and the importance of targeting this molecule in the treatment of various RAGE mediated pathologies.

• Highlights

• Receptor for advanced glycation end products (RAGE) is a member of immunoglobulin superfamily of receptors and involved in many pathophysiological conditions.

• RAGE ligation with its ligands leads to initiation of distinct signaling cascades and activation of numerous transcription factors.

• Targeting RAGE signaling through inhibitors and anti-RAGE antibodies can be promising treatment strategy.

摘要

晚期糖基化终产物受体 (RAGE) 是一种存在于细胞表面的免疫球蛋白样受体。RAGE 与一系列结构不同的配体结合，充当模式识别受体 (PRR)，并在执行不同功能的不同来源的细胞上表达。RAGE 连接导致一系列信号事件的启动，并与炎症、癌症、糖尿病、血管功能障碍、视网膜病变和神经退行性疾病等疾病有关。由于 RAGE 与许多疾病的进展密切相关，RAGE 信号已通过使用抑制剂和抗 RAGE 抗体作为治疗策略和疗法成为目标。在这篇评论中，

• 强调

• 晚期糖基化终产物受体 (RAGE) 是免疫球蛋白受体超家族的成员，参与多种病理生理状况。

• RAGE 与其配体的连接导致不同信号级联反应的启动和众多转录因子的激活。

• 通过抑制剂和抗 RAGE 抗体靶向 RAGE 信号可能是有前途的治疗策略。