Transition Metal and Inner Transition Metal Catalyzed Amide Derivatives Formation through Isocyanide Chemistry,Synthesis

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Transition Metal and Inner Transition Metal Catalyzed Amide Derivatives Formation through Isocyanide Chemistry
Synthesis ( IF 2.6 ) Pub Date : 2020-09-15 , DOI: 10.1055/s-0040-1707357
Morteza Shiri _{1,

2} , Noushin Farajinia-Lehi ₁ , Parvin Salehi ₁ , Zahra Tanbakouchian ₁

Affiliation

This paper is dedicated to Emeritus Professor, Dr. Nasser Iranpoor (Shiraz University) on the occasion of his 67^th birthday.

Abstract

The synthesis of amides is a substantial research area in organic chemistry because of their ubiquitous presence in natural products and bioactive molecules. The use of easily accessible isocyanides as amidoyl (carbamoyl) synthons in cross-coupling reactions using transition metal and inner transition metöal catalysts is a current trend in this area. Isocyanides, owing to their coordination ability as a ligand and inherent electronic properties for reactions with various partners, have expanded the potential application of these transformations for the preparation of novel synthetic molecules and pharmaceutical candidates. This review gives an overview of the achievements in isocyanide-based transition metal and inner transition metal catalyzed amide formation and discusses highlights of the proposed distinct mechanisms.

1 Introduction

2 Synthesis of Arenecarboxamides

3 Synthesis of Alkanamides

4 Synthesis of Cyclic Amides

5 Formation of Alkynamides

6 Formation of Acrylamide-like Molecules

7 Formation of Ureas and Carbamates

8 Conclusion

Publication History

Received: 04 June 2020

Accepted: 28 July 2020

Publication Date:
15 September 2020 (online)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

中文翻译：

异氰酸酯化学法合成过渡金属和内过渡金属催化的酰胺衍生物的形成

本文是专门为名誉教授，纳赛尔博士Iranpoor（设拉子大学）在他67之际^个生日。

抽象

酰胺的合成是有机化学的重要研究领域，因为它们普遍存在于天然产物和生物活性分子中。在使用过渡金属和内部过渡金属催化剂的交叉偶联反应中，易于获得的异氰化物作为酰胺基（氨基甲酰基）合成子的使用是该领域的当前趋势。异氰酸酯由于其作为配体的配位能力和与各种配偶体反应的固有电子性质，已扩展了这些转化在制备新型合成分子和候选药物中的潜在应用。这篇综述概述了基于异氰化物的过渡金属和内部过渡金属催化的酰胺形成的成就，并讨论了所提出的独特机理的重点。

1引言

2芳酰胺的合成

3烷酰胺的合成

4环酰胺的合成

5烷基酰胺的形成

6丙烯酰胺样分子的形成

7尿素和氨基甲酸酯的形成

8结论