Bacterial enteric pathogens individually and collectively represent a serious global health burden. Humoral immune responses following natural or experimentally-induced infections are broadly appreciated to contribute to pathogen clearance and prevention of disease recurrence. Herein, we have compared observations on humoral immune mechanisms following infection with Citrobacter rodentium, the model for enteropathogenic Escherichia coli, Vibrio cholerae, Shigella species, Salmonella enterica species, and Clostridioides difficile. A comparison of what is known about the humoral immune responses to these pathogens reveals considerable variance in specific features of humoral immunity including establishment of high affinity, IgG class-switched memory B cell and long-lived plasma cell compartments. This article suggests that such variance could be contributory to persistent and recurrent disease.

细菌性肠道病原体单独和集体代表严重的全球健康负担。自然或实验诱导感染后的体液免疫反应被广泛认为有助于病原体清除和预防疾病复发。在此，我们比较了感染后体液免疫机制的观察结果。柠檬酸杆菌, 肠病模型 大肠杆菌、霍乱弧菌、志贺氏菌 物种, 沙门氏菌 物种，和 艰难梭菌. 对这些病原体的体液免疫反应的已知比较揭示了体液免疫的特定特征的相当大的差异，包括高亲和力、IgG 类别转换记忆 B 细胞和长寿命浆细胞区室的建立。这篇文章表明，这种差异可能是导致疾病持续和复发的原因。