A low cost FeCl₃‐mediated cascade annulation of trifluoroacetimidoyl chlorides and hydrazides for the efficient synthesis of 5‐trifluoromethyl‐1,2,4‐triazoles has been developed. The transformation proceeds through a cascade base‐promoted intermolecular C−N bond formation and FeCl₃‐mediated intramolecular dehydration sequence under mild conditions. The protocol exhibits many notable features and can be readily scaled up to gram scale.

中文翻译：

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FeCl3介导的三氟乙酰亚胺基氯和酰肼合成5-三氟甲基-1,2,4-三唑的简便方法

已经开发出了一种低成本的FeCl ₃介导的三氟乙酰亚胺基氯和酰肼的级联环合法有效合成5-三氟甲基-1,2,4-三唑。在温和条件下，该转化过程通过级联碱基促进的分子间C-N键形成和FeCl ₃介导的分子内脱水序列进行。该协议具有许多显着的功能，可以很容易地放大到克级。