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COVID‐19 and hepatic involvement: The liver as a main actor of the pandemic novel
Scandinavian Journal of Immunology ( IF 3.7 ) Pub Date : 2020-09-15 , DOI: 10.1111/sji.12977
Cecilia Napodano 1 , Krizia Pocino 1 , Annunziata Stefanile 2 , Mariapaola Marino 3 , Luca Miele 1 , Francesca Gulli 4 , Valerio Basile 5 , Franco Pandolfi 1 , Antonio Gasbarrini 1 , Gian Ludovico Rapaccini 1 , Umberto Basile 2
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In the natural history of SARS‐CoV‐2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre‐existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID‐19 are still unclear but the liver damage in SARS‐CoV‐2 infection seems to be directly caused by virus‐induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS‐CoV‐2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID‐19 in patients with pre‐existing liver diseases.

中文翻译:

COVID‐19和肝脏受累:肝脏是大流行小说的主要角色

在SARS‐CoV‐2感染的自然史中,肝损伤是常见的,但程度较轻,这被定义为在疾病发展和感染治疗期间,无论是否患有肝病,均会发生肝损伤。尚不清楚COVID-19患者肝损伤的潜在机制,但SARS-CoV-2感染的肝损害似乎直接由病毒引起的细胞病变作用引起。在这篇综述中,我们将总结有关SARS-CoV-2感染,急性反应和肝脏受累之间关系的最新文献资料。将概述肝损伤,肝移植以及原发性肝病患者可能发生的COVID-19后果。
更新日期:2020-09-15
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