Latinas are less likely to participate in genetic counseling (GC) and genetic testing (GT) than non‐Hispanic Whites. A multisite, randomized pilot study tested a culturally targeted educational intervention to increase uptake of GC/GT among Latina breast cancer (BC) survivors (N = 52). Participants were recruited in Tampa, FL and Ponce, PR and randomized to: (a) fact sheet about BC survivorship (control) or (b) a culturally targeted educational booklet about GC/GT (intervention). Participants in the intervention condition were also offered no‐cost telephone GC followed by free GT with mail‐based saliva sample collection. Participants self‐reported hereditary breast and ovarian cancer (HBOC) knowledge and emotional distress at baseline and 1‐ and 3‐month follow‐ups. We used logistic regression to examine differences in GC/GT uptake by study arm (primary outcome) and repeated measures ANOVA to examine the effects of study arm and time on HBOC knowledge and emotional distress (secondary outcomes). Compared to the control arm, intervention participants were more likely to complete GC (OR_Intervention = 13.92, 95% CI = 3.06–63.25, p < .01) and GT (OR_Intervention = 12.93, 95% CI = 2.82–59.20, p < .01). Study site did not predict uptake of GC (p = .08) but Ponce participants were more likely to complete GT (OR_Ponce = 4.53, 95% CI = 1.04–19.72, p = .04). ANOVAs demonstrated an increase in HBOC knowledge over time across both groups (F(2,88) = 12.24, p < .01, η_p² = 0.22). We also found a significant interaction of study arm and time, such that intervention participants demonstrated a greater and sustained (to the 3‐month follow‐up) increase in knowledge than control participants (F(2,88) = 3.66, p = .03, η_p² = 0.08). No other main or interaction effects were significant (all p’s> .15). Study findings demonstrate the potential of our culturally targeted print intervention. Lessons learned from this multisite pilot study for enhancing GC/GT in Latinas include the need to attend to both access to GC/GT and individual factors such as attitudes and knowledge.

中文翻译：

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一项旨在增加拉丁裔乳腺癌幸存者的遗传咨询和基因检测的教育干预试验性随机试验

与非西班牙裔白人相比，拉丁裔不太可能参与遗传咨询 (GC) 和基因检测 (GT)。一项多地点、随机试验研究测试了一种具有文化针对性的教育干预措施，以增加拉丁裔乳腺癌 (BC) 幸存者对 GC/GT 的吸收（N = 52)。参与者在佛罗里达州坦帕市和 PR Ponce 被招募，并随机分配到：（a）关于 BC 幸存者（控制）的情况说明书或（b）关于 GC/GT（干预）的文化针对性教育手册。干预条件下的参与者还获得了免费电话 GC，然后是免费的 GT 和基于邮件的唾液样本收集。参与者在基线和 1 个月和 3 个月的随访中自我报告了遗传性乳腺癌和卵巢癌 (HBOC) 知识和情绪困扰。我们使用逻辑回归来检查研究组的 GC/GT 摄取差异（主要结果），并使用重复测量方差分析来检查研究组和时间对 HBOC 知识和情绪困扰（次要结果）的影响。与对照组相比，干预参与者更有可能完成 GC（或_干预 = 13.92, 95% CI = 3.06–63.25, p  < .01) 和 GT (OR_干预 = 12.93, 95% CI = 2.82–59.20, p  < .01)。研究地点未预测 GC 的摄取 ( p  = .08)，但 Ponce 参与者更有可能完成 GT (OR _Ponce  = 4.53, 95% CI = 1.04–19.72, p  = .04)。方差分析表明，随着时间的推移，两组 HBOC 知识的增加（F (2,88) = 12.24，p  < .01，η _p ²  = 0.22）。我们还发现研究组和时间之间存在显着的交互作用，因此干预参与者比对照组参与者表现出更大且持续（至 3 个月的随访）的知识增长（F (2,88) = 3.66, p  = .03, η _p ²  = 0.08)。其他主效应或交互效应均不显着（所有p > .15）。研究结果证明了我们针对文化的印刷干预的潜力。从这项旨在提高拉丁美洲人的 GC/GT 的多站点试点研究中吸取的经验教训包括需要关注获得 GC/GT 的机会以及个人因素，例如态度和知识。