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EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker.
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2020-09-15 , DOI: 10.1111/jcmm.15852
Ruochan Chen 1, 2 , Yiya Zhang 1, 3, 4
Affiliation  

Hepatocellular carcinoma (HCC) has high mortality rate and is a serious disease burden globally. EPDR1 (ependymin related 1) is a member of piscine brain glycoproteins and is involved in cell adhesion. The gene expression, prognostic, and clinicopathological related data for EPDR1 were obtained from multiple transcriptome databases. Protein level of EPDR1 in HCC was verified using human protein atlas and CPTAC databases. EPDR1 co‐expressed genes were identified using LinkedOmics. Functional analysis of the co‐expressed genes was performed using gene set enrichment analysis, Gene Ontology, and KEGG. Statistical analysis was conducted in R. The relationship between EPDR1 expression and immune cell infiltration was analyzed using TIMER and CIBERSORT. The expression of EPDR1 was found to be significantly higher in HCC than in normal tissues. Further, EPDR1 level was correlated with advanced stage of HCC. EPDR1 was associated with multiple signaling, as well as cancer and apoptotic pathways. Further, EPDR1 expression was significantly correlated with purity and infiltration levels of various immune cells as well as immune signatures. This is the first study to report the role of EPDR1 in HCC. EPDR1 can be used as a novel prognostic biomarker as well as an effective target for diagnosis and treatment in HCC.

中文翻译:

EPDR1与肝细胞癌的免疫细胞浸润相关,可以用作预后的生物标志物。

肝细胞癌(HCC)死亡率高,在全球范围内是严重的疾病负担。EPDR1(与内皮素有关的1)是鱼类脑糖蛋白的成员,参与细胞粘附。EPDR1的基因表达,预后和临床病理相关数据均来自多个转录组数据库。使用人类蛋白质图谱和CPTAC数据库验证了肝癌中EPDR1的蛋白质水平。使用LinkedOmics鉴定了EPDR1共表达的基因。使用基因集富集分析,Gene Ontology和KEGG对共表达基因进行功能分析。在R中进行统计分析。使用TIMER和CIBERSORT分析EPDR1表达与免疫细胞浸润之间的关系。发现在肝癌中EPDR1的表达明显高于正常组织。进一步,EPDR1水平与肝癌晚期相关。EPDR1与多种信号传导以及癌症和凋亡途径相关。此外,EPDR1表达与各种免疫细胞的纯度和浸润水平以及免疫标记显着相关。这是第一个报告EPDR1在肝癌中的作用的研究。EPDR1可用作新型预后生物标志物,也是肝癌诊断和治疗的有效靶标。
更新日期:2020-10-22
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