Nowadays, nucleic acid therapy has become a promising way for the treatment of various malignant diseases. Cyclodextrin (CD)‐based nucleic acid delivery systems have attracted widespread attention due to the favorable chemical structures and excellent biological properties of CD. Recently, a variety of CD‐based nucleic acid delivery systems has been designed according to the different functions of CD for flexible gene therapies. In this review, the construction strategies and biomedical applications of CD‐based nucleic acid delivery systems are mainly focused on. The review begins with an introduction to the synthesis and properties of simple CD‐grafted polycations. Thereafter, CD‐related supramolecular assemblies based on different guest components are discussed in detail. Finally, different CD‐based organic/inorganic nanohybrids and their relevant functions are demonstrated. It is hoped that this brief review will motivate the delicate design of CD‐based nucleic acid delivery systems for potential clinical applications.

中文翻译：

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基于环糊精的核酸递送系统的多功能类型。

如今，核酸疗法已成为治疗各种恶性疾病的有前途的方法。由于环糊精（CD）的良好化学结构和出色的生物学特性，基于环糊精（CD）的核酸递送系统已引起广泛关注。最近，根据用于灵活基因疗法的CD的不同功能，设计了各种基于CD的核酸递送系统。在这篇综述中，基于CD的核酸递送系统的构建策略和生物医学应用主要侧重于此。这篇综述首先介绍了简单的CD接枝聚阳离子的合成和性质。此后，详细讨论了基于不同客体组分的CD相关超分子组装体。最后，展示了不同的基于CD的有机/无机纳米杂化物及其相关功能。希望这篇简短的评论将激发基于CD的核酸递送系统的微妙设计，以用于潜在的临床应用。