Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle.

mRNA前剪接是哺乳动物基因表达的基本过程，替代剪接在产生蛋白质多样性中起着广泛的作用。因为大多数基因都经历了前mRNA剪接，所以大多数细胞过程都取决于适当的剪接体功能。我们专注于细胞周期，并描述其对前mRNA剪接和准确的替代剪接的依赖性。我们概述了关键的细胞周期因子及其已知的剪接异构体。我们讨论了不同水平的mRNA剪接前调控，例如翻译后修饰和剪接因子表达的变化。我们描述了染色质动力学对细胞周期中的前mRNA剪接的影响。此外，我们专注于剪接体成分SF3B1，该成分在多种类型的癌症中都发生了突变，