The fused filament fabrication (FFF) technique was applied for the first time to fabricate novel 3D printed silicate bioactive and antibacterial Ag-doped glass-ceramic (Ag-BG) scaffolds. A novel filament consisting primarily of polyolefin and Ag-BG micro-sized particles was developed and its thermal properties characterized by thermogravimetric analysis (TGA) to define the optimum heat treatment with minimal macrostructural deformation during thermal debinding and sintering. Structural characteristics of the Ag-BG scaffolds were evaluated from macro- to nanoscale using microscopic and spectroscopic techniques. The compressive strength of the Ag-BG scaffolds was found to be in the range of cancellous bone. Bioactivity of the 3D printed Ag-BG scaffolds was evaluated in vitro through immersion in simulated body fluid (SBF) and correlated to the formation of an apatite-like phase. Methicillin-resistant Staphylococcus aureus (MRSA) inoculated with the Ag-BG scaffolds exhibited a significant decrease in viability underscoring a potent anti-MRSA effect. This study demonstrates the potential of the FFF technique for the fabrication of bioactive 3D silicate scaffolds with promising characteristics for orthopedic applications.

熔融长丝制造（FFF）技术首次应用于制造新颖的3D打印的硅酸盐生物活性和抗菌的银掺杂玻璃陶瓷（Ag-BG）支架。开发了一种主要由聚烯烃和Ag-BG微粒组成的新型长丝，并通过热重分析（TGA）表征了其热性能，从而定义了最佳的热处理工艺，在热脱脂和烧结过程中宏观结构变形最小。使用显微镜和光谱技术，从宏观到纳米尺度评估了Ag-BG支架的结构特征。发现Ag-BG支架的抗压强度在松质骨的范围内。在体外评估了3D打印的Ag-BG支架的生物活性通过浸入模拟体液（SBF）中并与磷灰石样相的形成相关。接种了Ag-BG支架的耐甲氧西林金黄色葡萄球菌（MRSA）的生存能力显着下降，强调了有效的抗MRSA作用。这项研究证明了FFF技术在生物活性3D硅酸盐支架制造方面的潜力，该支架可用于骨科应用。