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Effect of ethylparaben on the growth and development of Drosophila melanogaster on preadult.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-16 , DOI: 10.1016/j.etap.2020.103495
Lin Gao 1 , Yajuan Li 1 , Hongqin Xie 1 , Yuan Wang 1 , Haizhen Zhao 1 , Min Zhang 1 , Wei Gu 1
Affiliation  

Parabens are esters of p-hydroxybenzoic acid, including methylparaben (MP), ethylparaben (EP), propylparaben (PP), and the like. This substance has estrogenic and antiandrogenic effects, and a putative role in promoting cancer through endocrine disruption. By exposing Drosophila melanogaster to different concentrations of EP (300 mg/L, 700 mg/L, and 1000 mg/L), we investigated the effect of EP on the growth and development of D. melanogaster before emergence. We found that EP prolonged the development cycle of D. melanogaster, and changed the relative expression levels of Met, Gce, EcR, Kr-h1, and Br. In addition, EP reduced the titer of juvenile hormone Ⅲ (JH Ⅲ) and 20-hydroxyecdysone (20E), and delayed the peak of hormone secretion. This study provided a more objective and thorough assessment of safety for the parabens.



中文翻译:

对羟基苯甲酸乙酯对成年果蝇果蝇生长发育的影响。

对羟基苯甲酸酯是羟基苯甲酸的酯,包括对羟基苯甲酸甲酯(MP),对羟基苯甲酸乙酯(EP),对羟基苯甲酸丙酯(PP)等。该物质具有雌激素和抗雄激素作用,并通过内分泌破坏促进癌症。通过将果蝇暴露于不同浓度的EP(300 mg / L,700 mg / L和1000 mg / L),我们研究了EP在出芽前对D. melanogaster生长和发育的影响。我们发现EP延长了黑腹果蝇的发育周期,并改变了MetGceEcRKr-h1Br的相对表达水平。。另外,EP降低了少年Ⅲ激素(JHⅢ)和20-羟基蜕皮激素(20E)的效价,并延迟了激素分泌的高峰。这项研究为对羟基苯甲酸酯的安全性提供了更为客观和彻底的评估。

更新日期:2020-09-30
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