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Please, don't do it! Fifteen years of progress of non-invasive brain stimulation in action inhibition
Cortex ( IF 3.6 ) Pub Date : 2020-09-16 , DOI: 10.1016/j.cortex.2020.09.002
Sara Borgomaneri 1 , Gianluigi Serio 2 , Simone Battaglia 2
Affiliation  

The ability to inhibit prepotent responses is critical for survival. Action inhibition can be investigated using a stop-signal task (SST), designed to provide a reliable measure of the time taken by the brain to suppress motor responses. Here we review the major research advances using the combination of this paradigm with the use of non-invasive brain stimulation techniques in the last fifteen years. We highlight new methodological approaches to understanding and exploiting several processes underlying action control, which is critically impaired in several psychiatric disorders. In this review we present and discuss existing literature demonstrating i) the importance of the use of non-invasive brain stimulation in studying human action inhibition, unveiling the neural network involved ii) the critical role of prefrontal areas, including the pre-supplementary motor area (pre-SMA) and the inferior frontal gyrus (IFG), in inhibitory control iii) the neural and behavioral evidence of proactive and reactive action inhibition. As the main result of this review, the specific literature demonstrated the crucial role of pre-SMA and IFG as evidenced from the field of noninvasive brain stimulation studies. Finally, we discuss the critical questions that remain unanswered about how such non-invasive brain stimulation protocols can be translated to therapeutic treatments.



中文翻译:

拜托,不要这样做!行动抑制非侵入性脑刺激研究十五年

抑制优势反应的能力对于生存至关重要。可以使用停止信号任务(SST)来研究动作抑制,该信号旨在提供可靠的方法来衡量大脑抑制运动反应所花费的时间。在这里,我们回顾了过去十五年来使用这种范例与无创性脑刺激技术相结合的主要研究进展。我们重点介绍了新的方法论方法,以了解和利用动作控制下的多个过程,而在某些精神疾病中严重受损。在这篇评论中,我们提出并讨论了现有的文献,这些文献证明了i)使用非侵入性脑刺激在研究人类动作抑制中的重要性,揭示了涉及的神经网络ii)前额叶区域的关键作用,包括抑制作用前的辅助运动区(pre-SMA)和额下回(IFG),iii)抑制主动和反应作用的神经和行为证据。作为该综述的主要结果,特定文献证明了SMA前和IFG的关键作用,这一点已从无创性脑刺激研究领域得到证明。最后,我们讨论了关于如何将这种非侵入性脑刺激方案转化为治疗方法的悬而未决的关键问题。从非侵入性脑刺激研究领域可以证明,特定文献证明了SMA前和IFG的关键作用。最后,我们讨论了关于如何将这种非侵入性脑刺激方案转化为治疗方法的悬而未决的关键问题。从非侵入性脑刺激研究领域可以证明,特定文献证明了SMA前和IFG的关键作用。最后,我们讨论了关于如何将这种非侵入性脑刺激方案转化为治疗方法的悬而未决的关键问题。

更新日期:2020-10-11
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