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Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
Cell ( IF 64.5 ) Pub Date : 2020-09-16 , DOI: 10.1016/j.cell.2020.09.038
Carolyn Rydyznski Moderbacher 1 , Sydney I Ramirez 2 , Jennifer M Dan 2 , Alba Grifoni 1 , Kathryn M Hastie 1 , Daniela Weiskopf 1 , Simon Belanger 1 , Robert K Abbott 1 , Christina Kim 1 , Jinyong Choi 1 , Yu Kato 1 , Eleanor G Crotty 1 , Cheryl Kim 3 , Stephen A Rawlings 4 , Jose Mateus 1 , Long Ping Victor Tse 5 , April Frazier 1 , Ralph Baric 6 , Bjoern Peters 1 , Jason Greenbaum 1 , Erica Ollmann Saphire 2 , Davey M Smith 4 , Alessandro Sette 2 , Shane Crotty 2
Affiliation  

Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4+ and CD8+ T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4+ and CD8+ T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals ≥ 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that coordinated CD4+ T cell, CD8+ T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.



中文翻译:

急性 COVID-19 中针对 SARS-CoV-2 的抗原特异性适应性免疫及其与年龄和疾病严重程度的关系

关于抗原特异性免疫反应与 COVID-19 疾病严重程度之间关系的知识有限。我们在急性和恢复期受试者的 SARS-CoV-2 特异性 CD4 +和 CD8 + T 细胞以及中和抗体反应水平上完成了对适应性免疫所有三个分支的综合检查。SARS-CoV-2 特异性 CD4 +和 CD8 + T 细胞均与较轻的疾病相关。协调的 SARS-CoV-2 特异性适应性免疫反应与较轻的疾病相关,这表明 CD4 +和 CD8 + T 细胞在 COVID-19 的保护性免疫中发挥作用。值得注意的是,65 岁以上个体的 SARS-CoV-2 抗原特异性反应的协调被破坏。幼稚 T 细胞的稀缺也与衰老和不良的疾病结果有关。一种简单的解释是,协调的 CD4 + T 细胞、CD8 + T 细胞和抗体反应具有保护性,但不协调的反应常常无法控制疾病,这与衰老和对 SARS-CoV-2 的适应性免疫反应受损之间存在联系。

更新日期:2020-11-12
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