The outbreak of coronavirus disease (COVID-19) has caused a significant public health challenge worldwide. A lack of effective methods for screening potential patients, rapidly diagnosing suspected cases, and accurately monitoring of the epidemic in real time to prevent the rapid spread of COVID-19 raises significant difficulties in mitigating the epidemic in many countries. As effective point-of-care diagnosis tools, simple, low-cost and rapid sensors have the potential to greatly accelerate the screening and diagnosis of suspected patients to improve their treatment and care. In particular, there is evidence that multiple pathogens have been detected in sewage, including SARS-CoV-2, providing significant opportunities for the development of advanced sensors for wastewater-based epidemiology that provide an early warning of the pandemic within the population. Sensors could be used to screen potential carriers, provide real-time monitoring and control of the epidemic, and even support targeted drug screening and delivery within the integration of emerging mobile health (mHealth) technology. In this communication, we discuss the feasibility of an integrated point-of-care biosensor system with mobile health for wastewater-based epidemiology (iBMW) for early warning of COVID-19, screening and diagnosis of potential infectors, and improving health care and public health. The iBMW will provide an effective approach to prevent, evaluate and intervene in a fast, affordable and reliable way, thus enabling real-time guidance for the government in providing effective intervention and evaluating the effectiveness of intervention.

冠状病毒病（COVID-19）的爆发给全世界带来了重大的公共卫生挑战。由于缺乏有效的方法来筛查潜在患者、快速诊断疑似病例以及实时准确监测疫情以防止 COVID-19 的快速传播，给许多国家缓解疫情带来了重大困难。作为有效的现场诊断工具，简单、低成本、快速的传感器有可能大大加快疑似患者的筛查和诊断，从而改善他们的治疗和护理。特别是，有证据表明在污水中检测到了多种病原体，包括 SARS-CoV-2，这为开发用于基于废水的流行病学的先进传感器提供了重要机会，这些传感器可以对人群中的流行病提供早期预警。传感器可用于筛查潜在的携带者，提供对流行病的实时监测和控制，甚至支持在新兴移动医疗（mHealth）技术的集成中进行有针对性的药物筛查和输送。在本次交流中，我们讨论了基于废水流行病学的移动健康集成护理点生物传感器系统(iBMW)的可行性，该系统用于早期预警 COVID-19、筛查和诊断潜在感染者，并改进医疗保健和公共卫生。iBMW将以快速、经济、可靠的方式提供有效的预防、评估和干预方法，从而为政府提供有效干预和评估干预效果提供实时指导。