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Voluntary exercise enhances hippocampal theta rhythm and cognition in the rat.
Behavioural Brain Research ( IF 2.7 ) Pub Date : 2020-09-16 , DOI: 10.1016/j.bbr.2020.112916
Jia-Yi Li , Terry B.J. Kuo , Chang-Tsen Hung , Cheryl C.H. Yang

Regular exercise promotes learning and memory functions. Theta activity is known to relate to various cognitive functions. An increase in theta power may be related to higher cognitive functioning and learning functions. However, evidence is lacking to directly confirm that exercise training can increase the theta activity and promote various cognitive functions simultaneously. We hypothesize that long-term voluntary exercise increases the activity of hippocampal theta rhythm and enhances memory behavior. We used the voluntary wheel running model and a training period of 8 weeks. We started the training when the rats were 12 weeks old. Before and after intervention, we performed a 24 -h electrophysiological recording and 8-arm radial maze test to analyze the hippocampal theta rhythm in awake stage, and spatial memory functions. We discovered that middle to high range frequency (6.5–12 Hz) of theta power was increased after exercise intervention. In addition, the working memory error of 8-arm radial maze test in the exercise group decreased significantly after the 8 weeks of treatment, and these reductions were negatively correlated with hippocampal theta activity. Our results demonstrate that 8-weeks voluntary exercise increases both hippocampal theta amplitude and spatial memory in the rats.



中文翻译:

自愿运动增强了大鼠的海马 theta 节律和认知。

经常锻炼可以促进学习和记忆功能。众所周知,Theta 活动与各种认知功能有关。Theta 功率的增加可能与更高的认知功能和学习功能有关。然而,缺乏证据直接证实运动训练可以增加θ活动并同时促进各种认知功能。我们假设长期自愿运动会增加海马 theta 节律的活动并增强记忆行为。我们采用自愿轮跑模式,训练周期为 8 周。我们在大鼠 12 周大时开始训练。干预前后,我们进行了24小时电生理记录和8臂径向迷宫试验,以分析清醒期海马θ节律和空间记忆功能。我们发现运动干预后θ功率的中高频率(6.5-12Hz)增加。此外,运动组8臂径向迷宫试验的工作记忆误差在治疗8周后显着降低,且这些降低与海马θ活动呈负相关。我们的结果表明,8 周的自愿运动增加了大鼠的海马 theta 振幅和空间记忆。

更新日期:2020-09-16
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