Today, ureteral stent technology is making progress towards the reduction of complications and patient discomfort. Therefore, magnesium alloys have become excellent candidate materials for manufacturing ureteral stents due to their biodegradability and antibacterial activity. Built on our previous work on biodegradable magnesium alloys, this article reports a semisolid rheo-formed magnesium implant that displays degradability and biocompatibility in vivo, and feasibility as ureteral stents in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, whose grain size and shape factor were ca. 25.2 μm and ca. 1.56 respectively. Neither post-interventional inflammation nor pathological changes were observed in the urinary system during the implantation period of 14 weeks, and the degradation profile (14 weeks) meets the common requirement for the indwelling time of ureteral stents (8 to 16 weeks). Furthermore, histopathological observation and urinalysis results confirmed that the alloy had significantly higher antibacterial activity than the medical-grade stainless steel control. To our knowledge, this is the first in vivo study of biodegradable magnesium alloy as urinary implants in large animal models. Our results demonstrate that magnesium alloys may be a reasonable option for manufacturing biodegradable ureteral stents.

如今，输尿管支架技术在减少并发症和患者不适方面取得了进步。因此，镁合金由于其生物降解性和抗菌活性，已经成为用于制造输尿管支架的极好的候选材料。在我们之前关于可生物降解镁合金的工作的基础上，本文报道了一种半固态流变形式的镁植入物，该植入物在体内具有可降解性和生物相容性，以及在猪模型中作为输尿管支架的可行性。在流变形成的合金中观察到细化的非树枝状微观组织，其晶粒尺寸和形状因子为。25.2μm左右 1.56。在植入14周期间，泌尿系统未见介入后炎症或病理变化，并且降解曲线（14周）符合输尿管支架留置时间（8至16周）的一般要求。此外，组织病理学观察和尿液分析结果证实该合金具有比医学级不锈钢对照明显更高的抗菌活性。据我们所知，这是第一个体内大型动物模型中可生物降解镁合金作为尿道植入物的研究。我们的结果表明，镁合金可能是制造可生物降解输尿管支架的合理选择。