Induced pluripotent stem cells (iPSCs) are mainly characterized by their unlimited proliferation abilities and potential to develop into almost any cell type. The creation of this technology has been of great interest to many scientific fields, especially regenerative biology. However, concerns about the safety of iPSC application in transplantation have arisen due to the tumorigenic and immunogenic properties of iPSCs. This review will briefly introduce the developing history of somatic reprogramming and applications of iPSC technology in regenerative medicine. In addition, the review will highlight two challenges to the efficient usage of iPSCs and the underlying mechanisms of these challenges. Finally, the review will discuss the expanding application of iPSC technology in cancer immunotherapy as a potential cancer vaccine and its advantages in auxiliary treatment compared with oncofetal antigen-based and embryonic stem cell (ESC)-based vaccines.

诱导多能干细胞 (iPSC) 的主要特点是其无限增殖能力和发展成几乎任何细胞类型的潜力。这项技术的创造引起了许多科学领域的极大兴趣，尤其是再生生物学。然而，由于 iPSC 的致瘤性和免疫原性特性，引起了对移植中 iPSC 应用安全性的担忧。本综述将简要介绍体细胞重编程的发展历史和iPSC技术在再生医学中的应用。此外，审查将强调 iPSC 的有效使用面临的两个挑战以及这些挑战的潜在机制。最后，