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Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2020-09-15 , DOI: 10.2147/ijn.s269321
Yun-jing Hou , Xin-xin Yang , Rui-qi Liu , Di Zhao , Che-nxu Guo , An-chao Zhu , Mei-na Wen , Zhao Liu , Guo-fan Qu , Hong-xue Meng

Abstract: The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.

Keywords: pathological mechanism, nanoparticles, photothermal therapy, PTT, photodynamic therapy, PDT


中文翻译:

基于纳米粒子的光动力疗法和光热疗法的病理机制

摘要:基于纳米粒子的光疗的最终目的是杀死肿瘤,例如产生热量的光热疗法(PTT)和产生活性氧(ROS)并诱导多种抗肿瘤免疫力的光动力疗法(PDT)。 。另外,由于其在临床治疗中的强效性,最小的侵袭和可忽略的副作用,近年来受到了广泛的关注和研究。在本文中,分别描述了PTT和PDT中纳米材料的产生。在临床应用中,根据纳米粒子的不同组合途径,可用于治疗多种疾病,如肿瘤,黑素瘤,类风湿等。在本文中,

关键词:病理机制,纳米颗粒,光热疗法,PTT,光动力疗法,PDT
更新日期:2020-09-15
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