Redox homeostasis is regulated by critical molecules that modulate antioxidant and redox signaling (ARS) within the cell. Imbalances among these molecules can lead to oxidative stress and damage to cell functions, causing a variety of diseases. Brahma-related gene 1 (BRG1), also known as SMARCA4, is the central ATPase catalytic subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, which plays a core role in DNA replication, repair, recombination, and transcriptional regulation. Numerous recent studies show that BRG1 is involved in the regulation of various cellular processes associated with ARS. BRG1, as a major factor in chromatin remodeling, is essential for the repair of oxidative stress-induced DNA damage and the activation of antioxidant genes under oxidative stress. Consequently, a comprehensive understanding of the roles of BRG1 in redox homeostasis is crucial to understand the normal functioning as well as pathological mechanisms. In this review, we summarized and discussed the role of BRG1 in the regulation of ARS.

中文翻译：

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BRG1在抗氧化和氧化还原信号中的作用

氧化还原稳态由调节细胞内抗氧化剂和氧化还原信号（ARS）的关键分子调节。这些分子之间的不平衡会导致氧化应激并损害细胞功能，从而导致多种疾病。梵天相关基因1（BRG1），也称为SMARCA4，是开关/蔗糖不可发酵（SWI / SNF）染色质重塑复合体的中央ATPase催化亚基，在DNA复制，修复，重组和转录中起核心作用规。最近的大量研究表明，BRG1参与了与ARS相关的各种细胞过程的调控。BRG1，作为染色质重塑的主要因素，对于氧化应激诱导的DNA损伤的修复和氧化应激下抗氧化剂基因的激活至关重要。所以，全面了解BRG1在氧化还原稳态中的作用对于了解正常功能以及病理机制至关重要。在这篇综述中，我们总结并讨论了BRG1在ARS调节中的作用。