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Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-09-15 , DOI: 10.1155/2020/6108342
Baochen Li 1 , Qiaoling Guo 1 , Yanyan Wang 1 , Rui Su 1 , Chong Gao 2 , Jinfang Zhao 3 , Xiaofeng Li 1 , Caihong Wang 1
Affiliation  

Objective. To investigate the relationship between serum interleukin-2 (IL-2) levels and disease activity, absolute numbers of peripheral lymphocyte subsets, autoantibodies, and associated cytokines in patients with rheumatoid arthritis (RA). Methods. This study included 106 patients with RA, evaluated their disease activity (DAS28 score), and divided them into disease remission (), low disease activity (), and moderate-high disease activity () groups. Flow cytometry was used to detect the absolute numbers of peripheral lymphocyte subpopulations and CD4+ T cell subsets in each group, and serum cytokine levels were measured using cytometric bead array. Results. Serum IL-2 levels in RA patients were positively correlated with disease activity and rheumatoid factor titers ( and , respectively), and multiple regression analysis revealed that serum IL-2 levels were an independent factor affecting disease activity. Serum IL-2 levels were positively correlated with Th17/Treg ratios (). Compared with the remission group, peripheral lymphocyte and CD4+ T lymphocyte subsets in patients with active RA decreased to varying degrees; however, the numbers of peripheral natural killer (NK) cells were significantly higher in the moderate-high disease activity group than in the remission () and low disease activity () groups; the percentages of NK cells had the same trend. In addition, the number and percentage of NK cells were positively correlated with serum IL-2 levels ( and , respectively). Conclusions. In RA patients, serum IL-2 levels were not only correlated with patients’ disease activity and autoantibody levels but were also involved in their Th17/Treg immune imbalance. In addition, in patients with active RA, NK cell levels were abnormally elevated, possibly due to high serum levels of IL-2.

中文翻译:

活动性类风湿关节炎患者血清白细胞介素 2 水平升高与外周血自然杀伤细胞水平异常有关

客观。研究类风湿关节炎 (RA) 患者血清白细胞介素 2 (IL-2) 水平与疾病活动、外周淋巴细胞亚群绝对数量、自身抗体和相关细胞因子之间的关系。方法。本研究纳入了 106 名 RA 患者,评估了他们的疾病活动度(DAS28 评分),并将他们分为疾病缓解组(),疾病活动度低 ()和中高疾病活动度 ()组。流式细胞仪检测各组外周血淋巴细胞亚群和CD4+T细胞亚群的绝对数量,流式细胞仪检测血清细胞因子水平。结果。RA患者血清IL-2水平与疾病活动度和类风湿因子滴度呈正相关。分别),多元回归分析显示血清IL-2水平是影响疾病活动的独立因素。血清 IL-2 水平与 Th17/Treg 比值呈正相关()。与缓解组相比,活动性RA患者外周淋巴细胞和CD4+T淋巴细胞亚群均有不同程度下降;然而,中高疾病活动组的外周自然杀伤(NK)细胞数量显着高于缓解组()和低疾病活动度 ()团体;NK细胞的百分比具有相同的趋势。此外,NK细胞的数量和百分比与血清IL-2水平呈正相关(分别)。结论。在 RA 患者中,血清 IL-2 水平不仅与患者的疾病活动度和自身抗体水平相关,而且还与他们的 Th17/Treg 免疫失衡有关。此外,在活动性 RA 患者中,NK 细胞水平异常升高,可能是由于血清 IL-2 水平高。
更新日期:2020-09-15
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