Background: Soy isoflavones and their metabolites such as equol have been associated with a reduced risk of hormone-sensitive tumors and metabolic syndromes. However, individual soy isoflavones and equol levels in atopic dermatitis remain uninvestigated. Objective: The aim of this study is to compare the levels of urinary daidzein, genistein, and equol between atopic dermatitis patients and normal subjects and to examine the correlation between equol concentration and the severity of clinical symptoms. Methods: A cross-sectional study was conducted at Akita University Hospital and Aso Iizuka Hospital in Japan. Fifty patients with confirmed atopic dermatitis diagnosis and 67 healthy controls were recruited. Daidzein, genistein, and equol in urine were measured by using a high-performance liquid chromatography-mass spectrometry system. Results: Urinary equol levels were significantly lower in the atopic dermatitis patients than in the healthy controls (p = 0.002). The difference was particularly noticeable in young people (6–19 years, p #x3c; 0.001). No correlations were found between urinary equol levels and the severity of clinical symptoms and laboratory data in the atopic dermatitis patients. Conclusion: Equol levels in childhood might be involved in the development of atopic dermatitis.
Int Arch Allergy Immunol

中文翻译：

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尿雌马酚水平与特应性皮炎患病率之间的联系。

背景：大豆异黄酮及其代谢物如雌马酚与降低激素敏感性肿瘤和代谢综合征的风险有关。然而，特应性皮炎中的个别大豆异黄酮和雌马酚水平仍未得到研究。目的：本研究的目的是比较特应性皮炎患者和正常人尿液中大豆苷元、染料木素和雌马酚的水平，并检查雌马酚浓度与临床症状严重程度之间的相关性。方法：在日本秋田大学医院和麻生饭冢医院进行了一项横断面研究。招募了 50 名确诊为特应性皮炎的患者和 67 名健康对照。使用高效液相色谱-质谱系统测定尿液中的大豆苷元、染料木素和雌马酚。结果：特应性皮炎患者的尿雌马酚水平显着低于健康对照组（p = 0.002）。这种差异在年轻人中尤为明显（6-19 岁，p #x3c；0.001）。在特应性皮炎患者中，未发现尿牛马酚水平与临床症状的严重程度和实验室数据之间存在相关性。结论：儿童期的雌马酚水平可能与特应性皮炎的发展有关。
Int Arch 过敏免疫