We report the synthesis of a degradable polyphosphoramidate via ring-opening metathesis polymerization (ROMP) with the Grubbs initiator (IMesH₂)(C₅H₅N)₂(Cl)₂Ru═CHPh. Controlled ROMP of a low ring strain diazaphosphepine-based cyclic olefin was achieved at low temperatures to afford well-defined polymers that readily undergo degradation in acidic conditions via the cleavage of the acid-labile phosphoramidate linkages. The diazaphosphepine monomer was compatible in random and block copolymerizations with phenyl and oligo(ethylene glycol) bearing norbornenes. This approach introduced partial or complete degradability into the polymer backbones. With this chemistry, we accessed amphiphilic poly(diazaphosphepine-norbornene) copolymers that could be used to prepare micellar nanoparticles.

中文翻译：

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通过开环复分解聚合可降解的聚氨基磷酸酯

_{我们报道了使用格鲁布斯引发剂 (IMesH 2} )(C ₅ H ₅ N) ₂ (Cl) ₂通过开环复分解聚合 (ROMP) 合成可降解的聚氨基磷酸酯Ru=CHPh。在低温下实现了低环应变二氮杂膦基环烯烃的受控 ROMP，以提供明确的聚合物，该聚合物在酸性条件下容易通过酸不稳定的氨基磷酸酯键的断裂而发生降解。二氮杂膦单体在与带有降冰片烯的苯基和低聚乙二醇的无规和嵌段共聚中是相容的。这种方法将部分或完全降解性引入到聚合物主链中。通过这种化学反应，我们获得了可用于制备胶束纳米颗粒的两亲性聚（二氮杂膦-降冰片烯）共聚物。