Type-1 diabetes (T1D) is caused by immune-mediated destruction of insulin-producing beta-cells, resulting in insulin deficiency and hyperglycemia. Islet transplantation is a potential treatment for T1D, but clinical implementation is hampered by islet availability and poor islet survival post-transplantation. To overcome these issues, we developed an intravascular multiside hole catheter with an interior polydimethylsiloxane (PDMS) bioscaffold capable of housing a cellular cargo. We used computational fluid dynamics to determine an optimized catheter design, which we then fabricated. Using our hybrid PDMS bioscaffold-intravascular catheter, we demonstrated that this platform can successfully maintain in vitro islet function and viability.

中文翻译：

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用于细胞疗法的混合聚二甲基硅氧烷生物支架血管内导管

1 型糖尿病 (T1D) 是由免疫介导的产生胰岛素的 β 细胞的破坏引起的，导致胰岛素缺乏和高血糖。胰岛移植是 T1D 的一种潜在治疗方法，但临床实施受到胰岛可用性和移植后胰岛存活率低的阻碍。为了克服这些问题，我们开发了一种血管内多侧孔导管，其内部聚二甲基硅氧烷 (PDMS) 生物支架能够容纳细胞货物。我们使用计算流体动力学来确定优化的导管设计，然后进行制造。使用我们的混合 PDMS 生物支架血管内导管，我们证明该平台可以成功地维持体外胰岛功能和活力。