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SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease.
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2020-09-25 , DOI: 10.1080/22221751.2020.1823890
Pengfei Wang 1 , Lihong Liu 1 , Manoj S Nair 1 , Michael T Yin 2 , Yang Luo 1 , Qian Wang 3 , Ting Yuan 1 , Kanako Mori 1 , Axel Guzman Solis 1 , Masahiro Yamashita 1 , Ankur Garg 4 , Lawrence J Purpura 2 , Justin C Laracy 2 , Jian Yu 1 , Leemor Joshua-Tor 4 , Joseph Sodroski 3 , Yaoxing Huang 1 , David D Ho 1
Affiliation  

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.



中文翻译:

严重疾病患者的 SARS-CoV-2 中和抗体反应更为强劲。

我们研究了 SARS-CoV-2 感染约 1 个月后 35 名患者的血浆抗体反应。与病毒核衣壳和刺突蛋白结合的抗体滴度在患有严重疾病的患者中显着更高。同样,针对 SARS-CoV-2 假病毒和活病毒的平均抗体中和滴度在病情较重的患者中更高,分别高出约 5 倍和约 7 倍。这些发现对那些追求血浆疗法、分离中和单克隆抗体和免疫决定因素的人具有重要意义。

更新日期:2020-09-25
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