Parkinson’s disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several studies report the association between intestinal dysbiosis and Parkinson’s disease, although a cause-effect relationship remains to be established. Herein, the gut microbiota composition of 64 Italian patients with Parkinson’s disease and 51 controls was determined using a next-generation sequencing approach. A real metagenomics shape based on gas chromatography-mass spectrometry was also investigated. The most significant changes within the Parkinson’s disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neuroprotective effects, particularly in the Lachnospiraceae family and key members, such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, and Blautia. The direct evaluation of fecal metabolites revealed changes in several classes of metabolites. Changes were seen in lipids (linoleic acid, oleic acid, succinic acid, and sebacic acid), vitamins (pantothenic acid and nicotinic acid), amino acids (isoleucine, leucine, phenylalanine, glutamic acid, and pyroglutamic acid) and other organic compounds (cadaverine, ethanolamine, and hydroxy propionic acid). Most modified metabolites strongly correlated with the abundance of members belonging to the Lachnospiraceae family, suggesting that these gut bacteria correlate with altered metabolism rates in Parkinson’s disease.

中文翻译：

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与帕金森病相关的肠道微生物群和代谢组变化。

帕金森病是一种神经退行性疾病，其特征是错误折叠的 α-突触核蛋白的细胞内聚集体沿脑轴聚集。几项研究报告了肠道菌群失调与帕金森病之间的关联，但因果关系仍有待确定。在此，使用新一代测序方法确定了 64 名意大利帕金森病患者和 51 名对照者的肠道微生物群组成。还研究了基于气相色谱-质谱法的真正宏基因组学形状。帕金森病组中最显着的变化突出了细菌分类群的减少，这与抗炎/神经保护作用有关，尤其是在毛螺科家族和关键成员，如Butyrivibrio、Pseudobutyrivibrio、Coprococcus和Blautia。粪便代谢物的直接评估揭示了几类代谢物的变化。脂质（亚油酸、油酸、琥珀酸和癸二酸）、维生素（泛酸和烟酸）、氨基酸（异亮氨酸、亮氨酸、苯丙氨酸、谷氨酸和焦谷氨酸）和其他有机化合物发生变化（尸胺、乙醇胺和羟基丙酸）。大多数修饰的代谢物与属于毛螺科家族成员的丰度密切相关，这表明这些肠道细菌与帕金森病的代谢率改变有关。