To guarantee sustainability and progress, the agrochemical industry is faced with several major challenges. Currently, loss of active ingredients due to consumer perception, changing grower needs and ever‐changing regulatory requirements is far higher than the number being introduced into the market. Therefore, there is a need to develop new products that can provide improved efficacy, selectivity and favorable environmental profiles. Strategies to achieve these goals are the search for acaricides and insecticides with new modes of action, or the discovery of novel molecules with activity on the most attractive target sites having resistance breaking properties against pest species. In this context, the introduction of halogen atoms or asymmetric centers into an active ingredient remains an important tool to modulate their properties, but so too is the pro‐pesticide concept. This review gives an overview of agrochemicals launched over the past 8 years, reflects new insights into known mechanisms of action, and describes the status and outlook for acaricide and insecticide discovery.

中文翻译：

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杀螨剂和杀虫剂发现的现状和展望。

为了保证可持续发展和进步，农化行业面临着几大挑战。目前，由于消费者认知、不断变化的种植者需求和不断变化的监管要求而导致的活性成分损失远远高于引入市场的数量。因此，需要开发能够提供改进的功效、选择性和有利的环境特征的新产品。实现这些目标的策略是寻找具有新作用方式的杀螨剂和杀虫剂，或者发现对最具吸引力的目标位点具有活性的新型分子，这些分子具有破坏害虫物种抗性的特性。在这种情况下，在活性成分中引入卤素原子或不对称中心仍然是调节其特性的重要工具，杀虫剂前体概念也是如此。本综述概述了过去 8 年推出的农用化学品，反映了对已知作用机制的新见解，并描述了杀螨剂和杀虫剂发现的现状和前景。