Dimethyl fumarate (DMF) causes a mean lymphocyte count drop of approximately 30% in relapsing–remitting multiple sclerosis (RRMS) patients. The relationship between this reduction and DMF effectiveness is controversial. The objective was to investigate if the decrease in absolute lymphocyte count (ALC) from baseline during DMF treatment is associated with clinical and magnetic resonance imaging (MRI) disease activity. A secondary aim was to evaluate ALC variations over time in a real‐life cohort of DMF‐treated patients.

中文翻译：

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富马酸二甲酯诱导的淋巴细胞计数下降与复发缓解型多发性硬化症的临床有效性有关。

在复发缓解型多发性硬化症 (RRMS) 患者中，富马酸二甲酯 (DMF) 导致平均淋巴细胞计数下降约 30%。这种减少与 DMF 有效性之间的关系是有争议的。目的是调查在 DMF 治疗期间绝对淋巴细胞计数 (ALC) 从基线的减少是否与临床和磁共振成像 (MRI) 疾病活动相关。次要目的是评估 DMF 治疗患者的真实生活队列中 ALC 随时间的变化。