Seminars in Immunology ( IF 7.8 ) Pub Date : 2020-09-14 , DOI: 10.1016/j.smim.2020.101408 Nina Cortese 1 , Roberta Carriero 2 , Luigi Laghi 3 , Alberto Mantovani 4 , Federica Marchesi 5
Tumor tissues are populated by a multitude of macrophages, highly different in functional activity, localization and morphology. A clear contribution to disease progression has been shown in multiple cancer types, holding promise for the development of innovative macrophage-based prognostic tools. Current studies aimed at assessing the prognostic role of macrophages have documented the relevance of the macrophage population as a whole. However, dissecting the diversity of mononuclear phagocytes in tumor tissues has provided important information about the coexistence of distinct populations of macrophages with different prognostic significance. Here we summarize evidence of macrophage prognostic function in human cancer and focus on classical and modern strategies aimed at measuring macrophage features and deciphering their diversity. The wealth of new data generated will reshape our knowledge of macrophage complexity and hopefully foster the forthcoming development of these new metrics into prognostic tools as well as new therapeutic strategies.
中文翻译:
肿瘤相关巨噬细胞的预后意义:过去、现在和未来。
肿瘤组织由大量巨噬细胞组成,它们在功能活性、定位和形态上有很大差异。多种癌症类型已显示出对疾病进展的明显贡献,有望开发基于巨噬细胞的创新预后工具。当前旨在评估巨噬细胞预后作用的研究已经证明了巨噬细胞群作为一个整体的相关性。然而,解剖肿瘤组织中单核吞噬细胞的多样性提供了关于具有不同预后意义的不同巨噬细胞群共存的重要信息。在这里,我们总结了人类癌症中巨噬细胞预后功能的证据,并重点关注旨在测量巨噬细胞特征和破译其多样性的经典和现代策略。