Abstract Photodynamic therapy (PDT) shows great potential for tumor treatment owing to its high spatiotemporal selectivity, minimal invasiveness and patient compliance. However, the therapeutic effect of PDT is seriously hindered by the tumor hypoxia in vivo. Hypoxia is a typical hallmark of the solid tumor microenvironment, which promotes the proliferation, invasion and metastasis of tumor cells. Additionally, the oxygen consumption during PDT will further aggravate the tumor hypoxia, resulting in multiple undesirable side-effects. To resolve these problems, many studies have been conducted to improve the efficacy of PDT by increasing oxygen concentration in tumor. Here, we focus on the current advances in nanomaterials-mediated tumor oxygenation via oxygen-carrying or oxygen-generating strategies to relieve tumor hypoxia. Based on the comprehensive overview, we hope these inspirations in hypoxia-associated anti-tumor therapy will provide perspectives in designing new oxygenation nanomaterials in this promising field.

中文翻译：

---

缓解肿瘤缺氧的纳米材料用于增强光动力治疗

摘要 光动力疗法 (PDT) 由于其高时空选择性、微创性和患者依从性而在肿瘤治疗中显示出巨大的潜力。然而，体内肿瘤缺氧严重阻碍了PDT的治疗效果。缺氧是实体瘤微环境的典型标志，可促进肿瘤细胞的增殖、侵袭和转移。此外，PDT过程中的耗氧量会进一步加剧肿瘤缺氧，导致多种不良副作用。为了解决这些问题，已经进行了许多研究以通过增加肿瘤中的氧浓度来提高PDT的功效。在这里，我们关注纳米材料介导的肿瘤氧合通过携氧或产氧策略缓解肿瘤缺氧的当前进展。