Introduction

Trauma, hemorrhage, and peritonitis have widely varying impacts on endocrine response in the injured patient. We sought to examine cortisol response in established non-human primate models of traumatic hemorrhage and intra-abdominal contamination.

Methods

Cynomologus Macaques were separated into two experimental groups, the polytrauma and hemorrhage model, involving a laparoscopic liver resection with uncontrolled hemorrhage, cecal perforation, and soft tissue excision; and the traumatic hemorrhage model, involving only liver resection and uncontrolled hemorrhage. Cortisol levels were measured pre-operatively, at the time of injury, and at regular intervals until post-operative day 1.

Results

Cortisol levels increased 600% from the pre-operative value in the polytrauma and hemorrhage model, with minimal changes (20%) in the hemorrhage only model.

Conclusion

Cortisol levels increase dramatically in response to polytrauma and intra-abdominal contamination as compared to hemorrhage only. The lack of response in the hemorrhage only group may be due to relative adrenal insufficiency caused by the shock state or lack of enticing stimuli from fecal peritonitis.

中文翻译：

---

猕猴中对创伤性出血和腹腔内污染模型的皮质醇反应的特征。

介绍

创伤，出血和腹膜炎对受伤患者的内分泌反应有广泛不同的影响。我们试图在创伤性出血和腹腔内污染的已建立的非人类灵长类动物模型中检查皮质醇的反应。

方法

食蟹猴分为两个实验组，多创伤和出血模型，包括腹腔镜肝切除术，出血不受控制，盲肠穿孔，软组织切除。和创伤性出血模型，仅涉及肝切除和失控性出血。术前，受伤时和术后第1天定期测量皮质醇水平。

结果

在多创伤和出血模型中，皮质醇水平较术前值增加了600％，而在仅出血模型中，皮质醇水平的变化很小（20％）。

结论

与仅出血相比，皮质醇水平在应对多创伤和腹腔内污染时急剧增加。仅出血组缺乏反应可能是由于休克状态引起的相对肾上腺皮质功能不全或粪便性腹膜炎缺乏诱人的刺激。