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Advanced glycation end-products and advanced oxidation protein products levels are correlates of duration of type 2 diabetes.
Life Sciences ( IF 6.1 ) Pub Date : 2020-09-15 , DOI: 10.1016/j.lfs.2020.118422
Firouzeh Heidari 1 , Soghra Rabizadeh 1 , Armin Rajab 1 , Farrokh Heidari 1 , Marjan Mouodi 1 , Hossien Mirmiranpour 1 , Alireza Esteghamati 1 , Manouchehr Nakhjavani 1
Affiliation  

Aims

Diabetes is associated with the excess formation of advanced glycation end-products (AGEs) and advanced oxidation protein products (AOPP), and low levels of ferric reducing ability of plasma (FRAP). However, the trend of oxidative and antioxidant markers levels according to diabetes duration is unclear.

Main methods

In a case-control study, 240 patients with diabetes and 100 healthy controls were enrolled. Patients were divided into four groups according to the duration of diabetes, including newly diagnosed, 1–5, 5–10, and 10–15 years. Serum AGEs, AOPP, and FRAP levels were compared among groups.

Key findings

AGEs and AOPP were higher and FRAP was lower in patients with diabetes compared to healthy controls. Serum levels of AGEs increased progressively with increasing in diabetes duration. AGEs levels were 68.97 ± 7.28% in newly-diagnosed, 73.43 ± 12.96% in 1–5 years and 80.44 ± 13.84% in 10–15 years of diabetes duration (pairwise p-values <0.05). In linear regression analysis the correlation among AGEs, AOPP, FRAP, and diabetes duration remained significant after adjustment for age, BMI, HDL, HbA1c, waist circumference, microvascular complications, and coronary artery diseases. ROC analysis showed AGEs could predict the duration of diabetes when patients with 10–15 years duration of diabetes were compared to patients with 1–5 years duration of diabetes (AUC = 0.676, p-value = 0.003).

Significance

Diabetes promotes AGEs, and AOPP production, independent of glycemic control and patients age. Serum levels of AGEs increase progressively with increasing duration of diabetes. AGEs may be helpful in estimating chronicity of diabetes.



中文翻译:

晚期糖基化终产物和晚期氧化蛋白产物水平与2型糖尿病持续时间相关。

目的

糖尿病与晚期糖基化终产物(AGEs)和晚期氧化蛋白产物(AOPP)的过量形成以及血浆铁还原能力低下(FRAP)有关。然而,根据糖尿病病程的长短,氧化和抗氧化标记物水平的趋势尚不清楚。

主要方法

在一项病例对照研究中,纳入了240名糖尿病患者和100名健康对照。根据糖尿病病程将患者分为四组,包括新诊断的1-5岁,5-10岁和10-15岁。比较各组的血清AGEs,AOPP和FRAP水平。

主要发现

与健康对照组相比,糖尿病患者的AGEs和AOPP较高,而FRAP较低。随着糖尿病持续时间的增加,AGEs的血清水平逐渐增加。新诊断的AGEs水平为68.97±7.28%,在1至5年的糖尿病患者中为73.43±12.96%,在10至15年的糖尿病患者中为80.44±13.84%(成对p值<0.05)。在线性回归分析中,调整年龄,BMI,HDL,HbA1c,腰围,微血管并发症和冠状动脉疾病后,AGEs,AOPP,FRAP和糖尿病病程之间的相关性仍然很显着。ROC分析显示,将10-15年糖尿病患者与1-5年糖尿病患者进行比较,AGEs可以预测糖尿病的持续时间(AUC = 0.676,p值= 0.003)。

意义

糖尿病可以促进AGEs和AOPP的产生,而与血糖控制和患者年龄无关。血清AGEs水平随着糖尿病持续时间的增加而逐渐增加。年龄可能有助于估计糖尿病的慢性病。

更新日期:2020-09-15
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