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Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells.
Immunity ( IF 32.4 ) Pub Date : 2020-09-15 , DOI: 10.1016/j.immuni.2020.08.007 Maike Effern 1 , Michael Hölzel 1
中文翻译:
不甜:来自瘤内髓样细胞的糖皮质激素会禁用T细胞。
更新日期:2020-09-15
Immunity ( IF 32.4 ) Pub Date : 2020-09-15 , DOI: 10.1016/j.immuni.2020.08.007 Maike Effern 1 , Michael Hölzel 1
Affiliation
In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8+ T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.
中文翻译:
不甜:来自瘤内髓样细胞的糖皮质激素会禁用T细胞。
在本期中,Acharya等人。证明巨噬细胞和单核细胞在肿瘤微环境中产生的糖皮质激素诱导功能障碍的CD8 + T细胞表型。阻断髓样糖皮质激素生成可增强肿瘤的免疫监测和对免疫检查点治疗的反应性。