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Star-shaped polycaprolactone bearing mussel-inspired catechol end-groups as a promising bio-adhesive
European Polymer Journal ( IF 6 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.eurpolymj.2020.110025
Youjun He , Jiming Chen , Irum Rafique , Zaijun Lu

Abstract The catechol groups in mussel adhesive proteins exhibit excellent adhesion property to the skin and tissue surfaces. Inspired by catechol groups, the aim of this study is to synthesize the star-shaped polycaprolactone bio-adhesive bearing catechol end-groups (s-PCL19-CA9). Firstly, star-shaped polycaprolactone was synthesized through ring-opening polymerization of caprolactone monomers initiated by β-cyclodextrin, and then the s-PCL19-CA9 was obtained through end-group functionalization using succinic anhydride and dopamine. The structure of s-PCL19-CA9 was characterized by 1H NMR, FTIR, and static light scattering. Adhesive strength measurements demonstrate that the incorporation of multifunctional catechol groups endows the crosslinked s-PCL19-CA9 with an excellent adhesion property (102 ± 10 kPa). The swelling ratio of crosslinked s-PCL19-CA9 is as low as 3.4 ± 0.2% owing to the hydrophobicity of PCL and the crosslinking structures. Besides, the cytotoxicity studies show that s-PCL19-CA9 is noncytotoxic. The TGA measurements indicate that s-PCL19-CA9 possesses a good thermal stability. Therefore, this work provides a new way for developing multifunctional bio-adhesives with excellent adhesion property and low swelling ratio.

中文翻译:

带有受贻贝启发的儿茶酚端基的星形聚己内酯作为一种有前途的生物粘合剂

摘要 贻贝粘附蛋白中的儿茶酚基团对皮肤和组织表面表现出优异的粘附性能。受儿茶酚基团的启发,本研究的目的是合成带有儿茶酚端基的星形聚己内酯生物粘合剂 (s-PCL19-CA9)。首先,通过β-环糊精引发己内酯单体的开环聚合合成星形聚己内酯,然后使用琥珀酸酐和多巴胺通过端基官能化得到s-PCL19-CA9。s-PCL19-CA9 的结构通过 1H NMR、FTIR 和静态光散射表征。粘合强度测量表明,多功能儿茶酚基团的加入赋予交联的 s-PCL19-CA9 优异的粘合性能 (1​​02 ± 10 kPa)。由于 PCL 的疏水性和交联结构,交联 s-PCL19-CA9 的溶胀率低至 3.4 ± 0.2%。此外,细胞毒性研究表明 s-PCL19-CA9 无细胞毒性。TGA 测量表明 s-PCL19-CA9 具有良好的热稳定性。因此,这项工作为开发具有优异粘附性能和低溶胀率的多功能生物粘合剂提供了新的途径。
更新日期:2020-10-01
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