Objective

To investigate the influence of volatile organic compound (VOC) levels in blood, on hematological and serum biochemical parameters in the Canadian population.

Methods

We tested the association between seven selected VOCs and hematological profiles and serum tests reflecting liver and kidney function and glucose metabolism using a cross-sectional study design in 3950 participants of the Canadian Health Measures Survey from 2012 to 2015. We used generalized linear mixed models adjusting for age, sex, smoking, alcohol consumption, BMI, education and household income.

Results

An increase in blood concentration equivalent to the geometric mean for benzene, ethylbenzene, toluene, m-, p-xylenes, styrene, and total xylenes was associated with 0.68% (95% CI 0.36, 1.0) to 0.91% (95% CI 0.52, 1.3) increase in hemoglobin, and a 1.79% (95% CI 0.96, 2.62) to 4.11% (95% CI 3.11, 5.11) increase in total white blood cell count. Ethylbenzene, toluene, m-, p-xylenes and styrene were positively associated with increased platelet counts. A geometric mean increase for all VOCs was associated with decreases in creatinine. m- and p-xylenes were associated with a significant change in every measured blood cell count and liver function parameter, and in creatinine. Ethylbenzene was also positively associated with an increase in every measured hematologic parameter, two of the three liver function tests, and creatinine. Results were similar when stratified by age, but differed by smoking status and sex.

Conclusions

This study provides evidence that VOCs in blood, at levels found in the Canadian population, may influence blood cell counts and indicators of liver and kidney function, including an inverse association between serum VOC and creatinine. This novel finding merits further investigation to understand the impact of VOCs on human physiology and population health.

中文翻译：

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在一项基于人群的研究中，血液中的挥发性有机化合物与血液和生化特征的变化之间的关联。

目的

为了调查血液中挥发性有机化合物（VOC）水平对加拿大人群血液学和血清生化指标的影响。

方法

我们采用横断面研究设计，对2012年至2015年加拿大卫生措施调查的3950名参与者进行了七个选择的VOC与血液学特征和反映肝肾功能和葡萄糖代谢的血清测试之间的关联性测试。我们使用广义线性混合模型进行了调整年龄，性别，吸烟，饮酒，体重指数，教育和家庭收入。

结果

在血药浓度等同于苯，乙苯，甲苯，几何平均数的增加米- ，p -xylenes，苯乙烯，和总的二甲苯用0.68％（95％CI 0.36，1.0）关联到0.91％（95％CI 0.52 ，1.3）血红蛋白增加，白血球总数增加1.79％（95％CI 0.96，2.62）至4.11％（95％CI 3.11，5.11）。乙苯，甲苯，间二甲苯，对二甲苯和苯乙烯与血小板计数增加呈正相关。所有VOC的几何平均数增加均与肌酸酐的减少有关。m-和p-二甲苯与每个测得的血细胞计数和肝功能参数以及肌酐的显着变化有关。乙苯还与每个测量的血液学参数，三个肝功能测试中的两个和肌酐的升高呈正相关。按年龄分层时，结果相似，但吸烟状况和性别不同。

结论

这项研究提供的证据表明，血液中的VOC（以加拿大人群中的水平）可能会影响血细胞计数和肝肾功能指标，包括血清VOC和肌酐之间的负相关关系。这一新颖的发现值得进一步研究，以了解挥发性有机化合物对人类生理和人口健康的影响。