Rabies is a public health problem in the world especially in Côte d'Ivoire. The epidemiological surveillance of rabies revealed 10,197 exposures with 17 deaths in 2015 and 11,481 exposures with 18 deaths in 2016. The management of exposed people was based on WHO's intramuscular (IM) protocols (Essen and Zagreb). The usual results from these anti-rabies protocols showed low compliance corresponding to 45–50% exposed people who did not complete the Post Exposure Prophylaxis (PEP) schedule,mainly due to the cost of vaccines.

The main objective of the project was to test the feasibility of a free rabies PEP based on the Thai Red Cross (TRC) protocol used by intradermal route.

The study population was exposed people (patients) vaccinated in the anti-rabies center of Bouake and San Pédro which were two departments selected for this study. The TRC protocol was implemented in y ear 2017. Patients have been vaccinated according to IM post exposure protocols or by the TRC schedule.This new protocol was administered free of charge to exposed people with their consent. Patients who did not complete the PEP schedule were researched and interviewed for having the reasons related to this non-completion.

In 2017, 1625 exposures were registered including 1121 in Bouaké and 504 in San Pedro.

Overall immunization compliance was 63%. Patients who received the TRC schedule were 829 (52%)With 70% PEP compliance

The PEP compliance of Zagreb protocol was 67%%and the Essen protocol recorded 38% of PEP compliance. The research of exposed people who did not complete the PEP schedule has shown that cost effectively remains the major limiting factor among exposed people vaccinated by Essen or Zagreb protocols. But negligencewas main cause for the non-completion PEP among exposed people who accepted the TRC schedule. Introduction of free rabies PEP through the TRC protocol has found the population support. This experience has been successful with a better PEP compliance, which means safe protection of people from rabies.This study has demonstrate that free rabies vaccine used by ID route is one of the best solutions to improve the PEP compliance in Côte d'Ivoire.Nevertheless, alternatives ways should be provided in order to minimize vaccine wastage rates in anti-rabies center receiving very few exposed persons.Community engagementwould be necessary for more rabies awareness raising and improving bite victim's follow-up.

狂犬病是世界上的一个公共卫生问题，尤其是在科特迪瓦。狂犬病的流行病学监测显示，2015年有10,197例暴露，有17例死亡，2016年有11,481例暴露，有18例死亡。对暴露者的管理基于WHO的肌内（IM）方案（Essen和Zagreb）。这些抗狂犬病方案的通常结果显示，依从性较低，对应于没有完成暴露后预防（PEP）计划的45-50％暴露人群，这主要是由于疫苗成本的原因。

该项目的主要目的是测试基于皮内途径使用的泰国红十字会（TRC）协议的免费狂犬病PEP的可行性。

研究人群为在本研究选择的两个部门Bouake和SanPédro的反狂犬病中心接种疫苗的暴露人群（患者）。TRC方案于2017年初实施。根据IM暴露后方案或TRC时间表为患者接种了疫苗。该新方案在征得他们同意的情况下免费施用于暴露人群。对未完成PEP计划的患者进行了研究并进行了访谈，其原因与未完成PEP有关。

在2017年，共记录了1625次曝光，包括Bouaké的1121次和San Pedro的504次。

总体免疫依从性为63％。接受TRC时间表的患者为829（52％），PEP依从性为70％

Zagreb协议的PEP遵从性为67 %%，而Essen协议记录的PEP遵从性为38％。对未完成PEP计划的暴露人群的研究表明，在通过埃森或Zagreb方案接种疫苗的暴露人群中，成本有效仍然是主要限制因素。但是，过失是接受TRC时间表的暴露人群中未完成PEP的主要原因。通过TRC协议引入免费狂犬病PEP已获得人群的支持。这项经验取得了成功，并具有更好的PEP合规性，这意味着可以安全保护人们免受狂犬病的侵害。这项研究表明，ID路线使用的免费狂犬病疫苗是提高科特迪瓦PPE合规性的最佳解决方案之一。 ，