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Silver(I) Coordination Polymers: Photocatalytic Properties and Enhanced Treatment Activity of Haloperidol on Children Tic Disorder by Regulating Neurotransmitter Content.
Journal of Fluorescence ( IF 2.7 ) Pub Date : 2020-09-15 , DOI: 10.1007/s10895-020-02621-z
Hui-Li Qian 1 , Xin Yu 2 , Guo-Feng Liu 3
Affiliation  

In this article, the characterization, synthesis, as well as the photocatalysis dye degradation performance of two novel silver(I) coordination polymers, namely, [Ag(L)(Hbdc)]n (1, L = 1,4-Bis(5,6-dimethylbenzimidazol-1-yl)butane, H2bdc = 1,4-Benzenedicarboxylic acid) and [Ag2(L)(hip)]n (2, H2hip = 5-Hydroxyisophthalic acid), were investigated. Fascinatingly, the photocatalytic performance of Complexes 1 and 2 have been investigated, wherein Complex 2 is considered an excellent photocatalyst for degrading Rhodamine B/methyl violet/methylene blue mixed organic dyes. Furthermore, the treatment activities of Complexes 1 and 2 on Tic disorder (TD) were assessed when used with haloperidol, and biochemical studies were conducted to reveal the mechanism in detail. Initially, the enzyme-linked immunosorbent assay was carried out to determine the dopamine and high vanillic acid contents in the striatum of the TD animal model. Subsequently, the reverse transcription-polymerase chain reaction was utilized to determine the relative expression of dopamine 1 and 2 receptor.



中文翻译:

银(I)配位聚合物:氟哌啶醇通过调节神经递质含量对儿童抽动症的光催化性能和增强的治疗活性。

在本文中,两种新型银(I)配位聚合物[Ag(L)(Hbdc)] n1,L = 1,4-Bis()的表征,合成以及光催化染料的降解性能研究了5,6-二甲基苯并咪唑-1-基)丁烷,H 2 bdc = 1,4-苯二甲酸)和[Ag 2(L)(hip)] n2,H 2 hip = 5-羟基间苯二甲酸) 。令人着迷的是,研究了配合物12的光催化性能,其中配合物2被认为是降解若丹明B /甲基紫/亚甲基蓝混合有机染料的极好光催化剂。此外,与氟哌啶醇一起使用时,评估了复合物12对抽动症(TD)的治疗活性,并进行了生化研究以详细揭示其机制。最初,进行了酶联免疫吸附测定,以确定TD动物模型纹状体中的多巴胺和高香草酸含量。随后,利用逆转录聚合酶链反应确定多巴胺12受体的相对表达。

更新日期:2020-09-15
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