Alterations in the immune system with aging are considered to underlie many age-related diseases. However, many elderly individuals remain healthy until even a very advanced age. There is also an increase in numbers of centenarians and their apparent fitness. We should therefore change our unilaterally detrimental consideration of age-related immune changes. Recent data taking into consideration the immunobiography concept may allow for meaningful distinctions among various aging trajectories. This implies that the aging immune system has a homeodynamic characteristic balanced between adaptive and maladaptive aspects. The survival and health of an individual depends from the equilibrium of this balance. In this article, we highlight which parts of the aging of the immune system may be considered adaptive in contrast to those that may be maladaptive.

随着年龄的增长，免疫系统的变化被认为是许多与年龄有关的疾病的基础。然而，许多老年人甚至在非常高龄之前都保持健康。百岁老人的数量及其明显的健康状况也有所增加。因此，我们应该改变对与年龄相关的免疫变化的单方面不利考虑。考虑到免疫传记概念的最新数据可能允许在各种衰老轨迹之间进行有意义的区分。这意味着老化的免疫系统具有在适应性和适应不良方面平衡的同源动力学特征。一个人的生存和健康取决于这种平衡的平衡。在本文中，