Fragrances are extensively applied in food, daily chemicals, tobacco and medicine industries. However, too strong volatility of fragrances results in a fast release rate, thereby reducing the usage time of aromatherapy products. Although loading fragrances into nanomaterials is capable of slowing their rates of release, the encapsulation efficiency of traditional nanomaterials is very low, and the nanomaterials themselves are not stable. Herein, hollow mesoporous silica nanoparticles (hMSNs) were designed for encapsulation of eugenol and the nano-fragrance was named EG@hMSNs. The structure of hMSNs was stable and the encapsulation rate of eugenol reached 46.5%. Besides, EG@hMSNs could significantly slow the release rate of eugenol. Subsequently, the EG@hMSNs were testified that they had positive roles in stress relief by open field tests. The molecular mechanisms of these positive effects on the central nervous system were then explored. Furthermore, the preparation method of hMSCs was simple, and the preparation cost was low. Therefore, EG@hMSNs are expected to be industrially produced and have a great application prospect.

中文翻译：

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负载丁香酚的中孔二氧化硅纳米粒子用于调节中枢神经系统。

香料广泛应用于食品，日用化工，烟草和医药行业。然而，香料的挥发性太强导致释放速度快，从而减少了芳香疗法产品的使用时间。尽管将香料装载到纳米材料中能够减慢其释放速率，但是传统纳米材料的封装效率非常低，并且纳米材料本身也不稳定。本文中，中空介孔二氧化硅纳米粒子（hMSNs）被设计用于丁香酚的包封，并且该纳米香料被称为EG @ hMSNs。hMSNs结构稳定，丁子香酚的包封率达到46.5％。此外，EG @ hMSNs可以显着降低丁子香酚的释放速率。随后，EG @ hMSNs通过露天试验证明它们在缓解压力中具有积极作用。然后探讨了这些对中枢神经系统产生积极影响的分子机制。而且，hMSCs的制备方法简单，制备成本低。因此，EG @ hMSNs有望实现工业化生产，具有广阔的应用前景。