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Ethics of research on stem cells and regenerative medicine: ethical guidelines in the Islamic Republic of Iran.
Stem Cell Research & Therapy ( IF 7.5 ) Pub Date : 2020-09-14 , DOI: 10.1186/s13287-020-01916-z
Leila Afshar 1 , Hamid-Reza Aghayan 2 , Jila Sadighi 3 , Babak Arjmand 2 , Seyed-Mahmoud Hashemi 4 , Mohsen Basiri 5 , Reza Omani Samani 6 , Mohammad Kazemi Ashtiani 7 , Seyed-Ali Azin 8 , Ensiyeh Hajizadeh-Saffar 9 , Ehsan Shamsi Gooshki 10 , Amir-Ali Hamidieh 11 , Mohammad-Reza Rezania Moallem 6 , Seyed-Mohammad Azin 6 , Sadegh Shariatinasab 6 , Mehdi Soleymani-Goloujeh 5 , Hossein Baharvand 5, 12
Affiliation  

Regenerative medicine plays a major role in biomedicine, and given the ever-expanding boundaries of this knowledge, numerous ethical considerations have been raised. Rapid advancement of regenerative medicine science and technology in Iran, emerged the Iranian National Committee for Ethics in Biomedical Research to develop a comprehensive national ethical guideline. Therefore, the present ethical guideline which comprises eleven chapters was developed in 2019 and approved in early 2020. The titles of these chapters were selected based on the ethical considerations of various aspects of the field of regenerative medicine: (1) ethical principles of research on stem cells and regenerative medicine; (2) ethical considerations for research on stem cells (embryonic stem cells, epiblast stem cells, tissue-specific stem cells, stem cells derived from transdifferentiation, induced pluripotent stem cells [iPSCs], germline pluripotent stem cells, germline stem cells, and somatic cell nuclear transfer [SCNT] stem cells); (3) ethical considerations for research on somatic cells in regenerative medicine (adult somatic cells, fetal tissue somatic cells, and somatic cells derived from pregnancy products [other than fetus]); (4) ethical considerations for research on gametes in regenerative medicine; (5) ethical considerations for research related to genetic manipulation (human and animal) in regenerative medicine; (6) ethical considerations for research on tissue engineering in regenerative medicine; (7) ethical considerations for pre-clinical studies in regenerative medicine; (8) ethical considerations for clinical trials in regenerative medicine; (9) ethical considerations for stem cells and regenerative medicine bio-banks; (10) ethical considerations for privacy and confidentiality; and (11) ethical considerations for obtaining informed consent. This article discusses the process of developing the present ethical guidelines and its practical points. We hope that it can play an important worldwide role in advancing ethics of research on stem cells and regenerative medicine.

中文翻译:

干细胞和再生医学研究伦理:伊朗伊斯兰共和国的伦理准则。

再生医学在生物医学中起着重要的作用,鉴于这一知识的范围不断扩大,人们提出了许多伦理学的考虑。伊朗再生医学科学技术的飞速发展,产生了伊朗国家生物医学伦理委员会,以制定全面的国家伦理准则。因此,本道德准则由11章组成,于2019年制定,并于2020年初获得批准。这些章的标题是根据再生医学领域各个方面的伦理考虑而选择的:(1)研究再生医学的伦理原则干细胞和再生医学;(2)研究干细胞(胚胎干细胞,表皮干细胞,组织特异性干细胞,源自转分化的干细胞,诱导多能干细胞[iPSC],种系多能干细胞,种系干细胞和体细胞核移植[SCNT]干细胞);(3)研究再生医学中的体细胞(成人体细胞,胎儿组织体细胞和源自妊娠产物[胎儿]以外的体细胞)的伦理学考虑;(4)研究再生医学配子的伦理考虑;(5)与再生医学中的基因操纵(人类和动物)有关的研究的伦理考虑;(6)再生医学组织工程研究的伦理考虑;(7)再生医学的临床前研究的伦理学考虑;(8)再生医学临床试验的伦理考虑;(9)关于干细胞和再生医学生物库的伦理考虑;(10)隐私和保密的道德考量;(11)获得知情同意的道德考量。本文讨论了制定本道德准则的过程及其实践要点。我们希望它可以在促进干细胞和再生医学研究伦理方面在世界范围内发挥重要作用。
更新日期:2020-09-14
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