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Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening.
BMC Cancer ( IF 3.8 ) Pub Date : 2020-09-14 , DOI: 10.1186/s12885-020-07283-5
Blanca Murillo-Ortiz 1 , Abraham Hernández-Ramírez 2 , Talia Rivera-Villanueva 3 , David Suárez-García 4 , Mario Murguía-Pérez 5 , Sandra Martínez-Garza 1 , Allyson Rodríguez-Penin 1 , Rosario Romero-Coripuna 1 , Xiomara Midory López-Partida 6
Affiliation  

Some evidence has shown that malignant breast tumours have lower electrical impedance than surrounding normal tissues. Electrical impedance could be used as an indicator for breast cancer detection. The purpose of our study was to analyse the sensitivity and specificity of electrical impedance mammography (EIM) and its implementation for the differential diagnosis of pathological lesions of the breast, either alone or in combination with mammography/ultrasound, in 1200 women between 25 and 70 years old. This study is a prospective, cross-sectional epidemiological observational study of serial screening. The women were invited to participate and signed a consent letter. Impedance imaging of the mammary gland was evaluated with the computerized mammography equipment of MEIK electroimpedance v.5.6. (0.5 mA, 50 kHz), developed and manufactured by PKF SIM-Technika®. The successful identification of breast cancer along with the sensitivity, specificity, and positive and negative predictive values of EIM were determined as follows: % sensitivity; % specificity; % positive predictive value (PPV); and % negative predictive value (NPV). EIM had a sensitivity of 85% and a specificity of 96%; the positive predictive value was 12%, and the negative predictive value was 99%. Seven cases were biopsy confirmed cancers. Significant correlations between the electrical conductivity index and body mass index (BMI) (p = 0.04) and patient age were observed (p = 0.01). We also observed that the average conductivity distribution increased according to age group (p = 0.001). We used the chi-squared test to assess the interactions between percent density and BMI (normal < 25 kg/m2 (n = 310), overweight 25–29.9 kg/m2 (n = 418) and obese ≥30 (n = 437)) (p < 0.05). The patients with a diagnosis of mammary carcinoma had a BMI of 35.51 kg/m2. Our results demonstrate that the use of monofrequency electrical impedance mammography (EIM) in the detection of breast cancer had a sensitivity and specificity of 85 and 96%, respectively. These findings may support future research in the early detection of breast cancer. EIM is a non-radiation method that may also be used as a screening method for young women with dense breasts and a high risk of developing breast cancer.

中文翻译:

单频电阻抗乳房X线摄影(EIM)诊断系统在乳腺癌筛查中的应用。

一些证据表明,恶性乳腺肿瘤的电阻抗低于周围正常组织。电阻抗可以作为乳腺癌检测的指标。我们研究的目的是分析电阻抗乳房 X 光检查 (EIM) 的敏感性和特异性,以及其在 1200 名 25 岁至 70 岁女性中单独或与乳房 X 光检查/超声相结合用于乳腺病理病变鉴别诊断的敏感性和特异性。岁了。本研究是一项连续筛查的前瞻性、横断面流行病学观察研究。这些妇女被邀请参加并签署了同意书。使用 MEIK electroimpedance v.5.6 的计算机化乳房 X 线摄影设备评估乳腺的阻抗成像。(0.5 mA,50 kHz),由 PKF SIM-Technika® 开发和制造。乳腺癌的成功鉴定以及 EIM 的敏感性、特异性以及阳性和阴性预测值确定如下:% 敏感性;%特异性;%阳性预测值(PPV);和%阴性预测值(NPV)。EIM 的敏感性为 85%,特异性为 96%;阳性预测值为12%,阴性预测值为99%。七例活检证实为癌症。观察到电导率指数和体重指数 (BMI) (p = 0.04) 与患者年龄 (p = 0.01) 之间存在显着相关性。我们还观察到平均电导率分布随着年龄组的增加而增加 (p = 0.001)。我们使用卡方检验来评估百分比密度与 BMI 之间的相互作用(正常 < 25 kg/m2 (n = 310)、超重 25–29.9 kg/m2 (n = 418) 和肥胖 ≥30 (n = 437) )(p < 0.05)。诊断为乳腺癌的患者BMI为35.51 kg/m2。我们的结果表明,使用单频电阻抗乳房 X 线摄影 (EIM) 检测乳腺癌的灵敏度和特异性分别为 85% 和 96%。这些发现可能支持未来乳腺癌早期检测的研究。EIM 是一种非辐射方法,也可用作乳房致密且患乳腺癌风险高的年轻女性的筛查方法。
更新日期:2020-09-14
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