Background: Multidrug-resistant (MDR) bacterial strain is a serious medical problem. Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to many antibiotics and is often associated with several diseases such as arthritis, osteomyelitis, and endocarditis. The development of an alternative treatment for eliminating MDR bacteria such as MRSA has attracted a considerable amount of research attention. Moreover, the development of a material for highly efficient generation of reactive oxygen species (ROS) involving two-photon photodynamic therapy (PDT) is currently desirable.
Materials and Methods: We present an example demonstrating that the use of water-soluble C₆₀(OH)₃₀ fullerenol with a 0.89 singlet oxygen quantum yield serving as a photosensitizer in PDT has the superior ability in effectively generating ROS.
Results: It has ultra-low energy (228.80 nJ pixel^{− 1}) and can perform 900 scans under two-photon excitation (TPE) in the near-infrared region (760 nm) to completely eliminate the MDR species. Furthermore, the favorable two-photon properties are absorption of approximately 760 nm in wavelength, absolute cross-section of approximately 1187.50 Göeppert–Mayer units, lifetime of 6.640 ns, ratio of radiative to nonradiative decay rates of approximately 0.053, and two-photon stability under TPE.
Conclusion: This enabled water-soluble C₆₀(OH)₃₀ fullerenol to act as a promising two-photon photosensitizer proceeding with PDT to easily eliminate MDR species.



中文翻译：

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水溶性富勒烯醇作为高效双光子光敏剂对抗多重耐药细菌的双光子光激发光动力疗法

背景：耐多药（MDR）细菌菌株是一个严重的医学问题。耐甲氧西林金黄色葡萄球菌(MRSA) 对许多抗生素具有耐药性，并且通常与多种疾病有关，例如关节炎、骨髓炎和心内膜炎。开发用于消除 MDR 细菌（如 MRSA）的替代疗法已引起大量研究关注。此外，目前需要开发一种涉及双光子光动力疗法（PDT）的高效产生活性氧（ROS）的材料。
材料和方法：我们举了一个例子，证明使用水溶性 C ₆₀ (OH) ₃₀具有0.89单线态氧量子产率的富勒烯醇作为PDT中的光敏剂具有有效产生ROS的优越能力。
结果：它具有超低能量（228.80 nJ 像素^-1），可在近红外区域（760 nm）的双光子激发（TPE）下进行 900 次扫描，完全消除 MDR 物种。此外，有利的双光子特性是吸收波长约为 760 nm，绝对截面约为 1187.50 Göeppert-Mayer 单位，寿命为 6.640 ns，辐射与非辐射衰减率之比约为 0.053，以及双光子稳定性在 TPE 下。
结论：这使得水溶性 C ₆₀ (OH) ₃₀富勒烯醇可作为一种有前途的双光子光敏剂，与 PDT 一起轻松消除 MDR 物种。