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An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance.
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-09-14 , DOI: 10.1039/d0bm01211d
Ximian Xiao 1 , Si Zhang , Sheng Chen , Yuxin Qian , Jiayang Xie , Zihao Cong , Danfeng Zhang , Jingcheng Zou , Wenjing Zhang , Zhemin Ji , Ruxin Cui , Zhongqian Qiao , Weinan Jiang , Yidong Dai , Yun Wang , Xiaoyan Shao , Yun Sun , Jiang Xia , Jian Fei , Runhui Liu
Affiliation  

Infections involving methicillin-resistant Staphylococcus aureus present great challenges, especially when biofilms and persister cells are involved. In this work, an α/β chimeric polypeptide molecular brush (α/β CPMB) is reported to show excellent performance in inhibiting the formation of biofilms and eradicating established biofilms. Additionally, the polymer brush efficiently killed metabolically inactive persister cells that are antibiotic-insensitive. Antimicrobial mechanism studies showed that α/β CPMB causes membrane disturbance and a substantial increase in reactive oxygen species (ROS) levels to kill bacteria, and mesosome-like structure formation was also observed. Furthermore, the polymer brush was able to kill clinically isolated multidrug resistant Gram-positive bacteria with no risk of antimicrobial resistance. The α/β CPMB has demonstrated great potential in addressing the great challenge of eradicating multidrug resistant Gram-positive bacterial infections.

中文翻译:

α/β嵌合肽分子刷,用于消除MRSA生物膜和持久性细胞,以减轻抗菌剂的耐药性。

涉及耐甲氧西林金黄色葡萄球菌的感染带来了巨大的挑战,特别是当涉及生物膜和持久性细胞时。在这项工作中,据报道,α/β嵌合多肽分子刷(α/βCPMB)在抑制生物膜形成和根除已建立的生物膜方面显示出优异的性能。此外,聚合物刷可有效杀死对抗生素不敏感的代谢不活跃的持久性细胞。抗菌机理研究表明,α/βCPMB会引起膜紊乱并显着增加活性氧(ROS)的水平以杀死细菌,并且还观察到了类似微粒体的结构形成。此外,聚合物刷能够杀死临床分离的耐多药革兰氏阳性细菌,而没有抗药性的风险。
更新日期:2020-09-22
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