Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral diet results in improved functional health, particularly at later ages. Meanwhile, pharmaceutical studies have demonstrated that botanical extracts have potent antiaging properties, capable of extending the mean lifespan of D. melanogaster by up to 25%, without a decrease in early fecundity. In this study, we combine these two different approaches to healthspan extension to examine whether a combination of such treatments results in a synergistic or antagonistic effect on Drosophila healthspan. One botanical extract, derived from Rhodiola rosea, mimicked the effects of the ancestral apple diet with better performance at later ages compared with the control. Another extract, derived from Rosa damascena, decreased age-specific survivorship when combined with the apple diet providing support for the “Poisoned Chalice” hypothesis that combinations of various supplements or diets can elicit adverse physiological responses. More experiments in model organisms should be completed researching the effects of combining healthspan-extending substances in various diet backgrounds.

中文翻译：

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饮食和植物补充剂：改善健康的联合疗法？

Healthspan 科学旨在为人类的生活增添健康、功能性的岁月。已经研究了许多不同的改善健康寿命的方法，主要集中在生物体健康的一个方面，例如生存。对黑腹果蝇的研究表明，逆转长期废弃的祖先饮食可改善功能健康，尤其是在晚年。同时，药物研究表明，植物提取物具有有效的抗衰老特性，能够延长黑腹果蝇的平均寿命高达 25%，而不会降低早期繁殖力。在这项研究中，我们将这两种不同的健康跨度扩展方法结合起来，以检查这些治疗的组合是否会对果蝇的健康跨度产生协同或拮抗作用。一种源自玫瑰红景天的植物提取物模仿祖先苹果饮食的效果，与对照相比，在后期表现更好。另一种提取物，来自大马士革蔷薇，当与苹果饮食相结合时，特定年龄的存活率降低，为“中毒圣杯”假说提供支持，即各种补充剂或饮食的组合会引起不利的生理反应。应该完成更多的模式生物实验，研究在各种饮食背景下结合延长健康期的物质的效果。