Introduction: The recurrence occurs frequently among patients with chronic rhinosinusitis with nasal polyps (CRSwNP), and predictors that could be conveniently detected during practice in outpatient service are needed. Objective: We aimed to illustrate that the concentration of Charcot-Leyden crystal (CLC) in nasal secretions can effectively and noninvasively predict polyp recurrence. Methods: 108 patients with CRSwNP were divided into recurrence (n = 68) and recurrence-free (n = 40) groups. Preoperative CLC concentrations in nasal secretions were collected and detected by ELISA. Polyp tissues were harvested during biopsy or endoscopic sinus surgery and were evaluated for inflammatory cells by histopathological staining. Demographic information and the clinical characteristics of each patient were reviewed for associations with recurrence. Binary logistic regression analysis was performed to determine predictive factors for polyp recurrence. Receiver operating characteristic (ROC) curves and the Youden index were performed to determine their predictive values. Survival analysis was performed to compare recurrence risk of patients with different CLC concentrations. Results: Sixty-eight (62.96%) patients developed recurrence during a 12- to 33-month postoperative follow-up. CLC concentrations in nasal secretions were positively correlated with eosinophil percent in polyp tissue and peripheral blood and were significantly higher in patients of the recurrence group than in the patients of the recurrence-free group (p #x3c; 0.001). Binary logistic regression and ROC curve demonstrated that CLC protein in nasal secretions is predictive of polyp recurrence. According to the Youden index, a CLC concentration of 34.24 ng/mL can predict postoperative polyp recurrence with 92.6% sensitivity and 87.5% specificity. Patients with CLC concentrations higher than the cutoff value yielded a higher risk of recurrence (p #x3c; 0.001, HR = 11.31, 95% CI: 6.41–19.98). Conclusions: CLC protein in nasal secretions may serve as a promising noninvasive biomarker to predict CRSwNP recurrence.
Int Arch Allergy Immunol

中文翻译：

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Charcot-Leyden 晶体蛋白在鼻息肉复发性慢性鼻窦炎鼻腔分泌物中的预测意义。

简介：慢性鼻窦炎伴鼻息肉（CRSwNP）患者复发率高，需要在门诊实践中方便检测的预测因子。目的：我们旨在说明鼻分泌物中夏科-莱登晶体 (CLC) 的浓度可以有效且无创地预测息肉复发。方法：将108例CRSwNP患者分为复发（ n =68）和无复发（ n= 40) 组。收集鼻腔分泌物中的术前 CLC 浓度并通过 ELISA 检测。在活检或内窥镜鼻窦手术期间收集息肉组织，并通过组织病理学染色评估炎症细胞。回顾了每个患者的人口统计学信息和临床特征与复发的关联。进行二元逻辑回归分析以确定息肉复发的预测因素。执行受试者工作特征 (ROC) 曲线和约登指数以确定它们的预测值。进行生存分析以比较不同CLC浓度患者的复发风险。结果：在术后 12 至 33 个月的随访期间，68 名 (62.96%) 患者出现复发。鼻腔分泌物中的 CLC 浓度与息肉组织和外周血中的嗜酸性粒细胞百分比呈正相关，并且复发组患者的 CLC 浓度显着高于无复发组患者 ( p #x3c; 0.001)。二元逻辑回归和 ROC 曲线表明鼻分泌物中的 CLC 蛋白可预测息肉复发。根据约登指数，CLC 浓度为 34.24 ng/mL 可以预测术后息肉复发，敏感性为 92.6%，特异性为 87.5%。CLC 浓度高于临界值的患者产生更高的复发风险（p #x3c； 0.001，HR = 11.31，95% CI：6.41–19.98）。结论：鼻分泌物中的 CLC 蛋白可作为预测 CRSwNP 复发的有前途的无创生物标志物。
Int Arch 过敏免疫