Abstract

Transcatheter aortic valve replacement (TAVR) strongly depends on the calcification patterns, which may lead to a malapposition of the stented valve and complication onsets in terms of structure kinematics and paravalvular leakage (PVL). From one anatomical-resembling model of the aortic root, six configurations with different calcific deposits were built. TAVR fluid-structure interaction simulations predicted different outcomes for the different calcifications patterns in terms of the final valve configuration in the implantation site and the PVL estimations. In particular models with deposits along the cups coaptation resulted in mild PVL, while those with deposits along the attachment line in moderate PVL.

摘要

经导管主动脉瓣置换术 (TAVR) 强烈依赖于钙化模式，这可能导致支架瓣膜贴壁不良以及结构运动学和瓣周漏 (PVL) 方面的并发症发生。从主动脉根部的一种解剖学相似模型中，构建了具有不同钙化沉积物的六种结构。TAVR 流固耦合模拟根据植入部位的最终瓣膜配置和 PVL 估计预测了不同钙化模式的不同结果。尤其是沿着杯子接合处有沉积物的模型会导致轻度 PVL，而那些沿着附着线有沉积物的模型会导致中等 PVL。