Manganese dioxide (MnO₂)‐based functional nanomaterials have attracted great attention in the fields of nanoscience, biosensors, bioimaging, drug/gene delivery, and cancer therapy. Especially, all‐in‐one tumor microenvironment (TME) responsive MnO₂‐based nanoagents have become a research hotspot due to their simple fabrication procedure, high specific surface area, controllable size and morphologies, easy surface modification, TME response, and oxygen generation. This review aims to provide a comprehensive overview of strategies for construction of MnO₂‐based all‐in‐one nanoplatforms for cancer diagnosis and therapy. Major highlighted topics in this paper focus on the controllable fabrication of MnO₂ nanobuilding blocks, tumor targeting accumulation, working mechanisms of enhancing therapeutic efficacy, and the necessary considerations for construction of all‐in‐one nanoplatform. Finally, the current challenges and future directions in this rapidly growing research field are also discussed, which will provide guidance on the future works about the clinical translation of MnO₂‐based all‐in‐one nanoplatform.

中文翻译：

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基于智能二氧化锰的多合一纳米平台的构建，用于癌症诊断和治疗

基于二氧化锰（MnO ₂）的功能纳米材料在纳米科学，生物传感器，生物成像，药物/基因传递和癌症治疗领域引起了极大的关注。尤其是，基于肿瘤的微环境（TME）响应的基于MnO ₂的纳米复合剂已成为研究热点，因为它们的制备过程简单，比表面积高，尺寸和形态可控，易于表面修饰，TME响应和氧气生成。这篇综述旨在全面概述构建用于癌症诊断和治疗的基于MnO ₂的多合一纳米平台的策略。本文主要强调的主题集中在MnO ₂的可控制备上纳米构件，靶向肿瘤的积累，增强疗效的工作机制以及构建多合一纳米平台的必要注意事项。最后，还讨论了这个快速增长的研究领域中的当前挑战和未来方向，这将为有关基于MnO ₂的多合一纳米平台的临床翻译的未来工作提供指导。