Under the solvothermal conditions, by using the rigid π‐conjugated connector of H₄L (5,5′‐[1,3,6,8‐tetraoxobenzo [lmn] [3], [8] phenanthroline‐2‐7‐diyl] bis‐1,3‐benzenedicarboxylic acid) and the nitrogen‐donor auxiliary connector, two novel coordination polymers (CPs) based on Co ions as nodes {([Co(L)_0.5(bpy)(H₂O)]·3.5H₂O)}_n (1, bpy = 4,4′‐bipyridine) and {[Co(L)_0.5(1,4‐bib)(H₂O)₂]·2·5H₂O·DMA}_n (2, 1,4‐bib = 1,4‐bis[1‐imidazoly]benzene) have been synthesized. Furthermore, the treatment activities of the compounds on the pediatric chronic myocarditis were evaluated. The relative expression of the hs‐cTnT in the cardiomyocytes was determined by the real‐time reverse transcription‐polymerase chain reaction (RT‐PCR). The inflammatory cytokines content resealed by the cardiomyocytes was also determined using the enzyme linked immunosorbent assay (ELISA) detection kit.

中文翻译：

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两种Co（II）配位聚合物：通过降低心肌细胞中hs-cTnT的表达水平来抑制慢性心肌炎

在溶剂热条件下，使用H ₄ L的刚性π共轭连接器（5,5'-[1,3,6,8-四氧苯并[lmn] [3]，[8]菲咯啉-2-7-二基] bis-1,3-苯二甲酸）和氮供体辅助连接子，两种基于Co离子作为结点的新型配位聚合物（CP）{（[Co（L）_0.5（bpy）（H ₂ O）]·3.5 H ₂ O）} _n（1，bpy = 4,4'-联吡啶）和{[Co（L）_0.5（1,4-bib）（H ₂ O）₂ ]·2·5H ₂ O·DMA} _n（2，已合成1,4-bib = 1,4-双[1-咪唑基]苯）。此外，评估了该化合物对小儿慢性心肌炎的治疗活性。hs-cTnT在心肌细胞中的相对表达是通过实时逆转录聚合酶链反应（RT-PCR）确定的。还使用酶联免疫吸附测定（ELISA）检测试剂盒确定了心肌细胞重新密封的炎性细胞因子含量。